CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044450
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Clathrin heavy chain 1 
Protein Synonyms/Alias
  
Gene Name
 CLTC 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
24FKGNNRWKQSVELCKubiquitination[1, 2]
37CKKDSLYKDAMQYASubiquitination[1, 3, 4]
106PYFIQVMKEYLTKVDacetylation[5]
111VMKEYLTKVDAIKEKacetylation[5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 131 AA 
Protein Sequence
XEKHELIEFR RIAAYLFKGN NRWKQSVELC KKDSLYKDAM QYASESKDTE LAEELLQWFL 60
QEEKRECFGA CLFTCYDLLR PDVVLETAWR HNIMDFAMPY FIQVMKEYLT KVDAIKEKVK 120
VDSLTSLSLE D 131 
Gene Ontology
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR000547; Clathrin_H-chain/VPS_repeat.
 IPR011990; TPR-like_helical. 
Pfam
 PF00637; Clathrin 
SMART
  
PROSITE
  
PRINTS