| Tag | Content |
|---|
| CPLM ID | CPLM-009233 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Actin, cytoplasmic 1 |
Protein Synonyms/Alias | Beta-actin; Actin, cytoplasmic 1, N-terminally processed |
Gene Name | ACTB |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Bos taurus (Bovine) |
NCBI Taxa ID | 9913 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 50 | VMVGMGQKDSYVGDE | ubiquitination | [1] | | 61 | VGDEAQSKRGILTLK | ubiquitination | [1] | | 113 | TEAPLNPKANREKMT | ubiquitination | [1] | | 191 | DLTDYLMKILTERGY | ubiquitination | [1] | | 291 | KCDVDIRKDLYANTV | ubiquitination | [1] | | 315 | GIADRMQKEITALAP | ubiquitination | [1] | | 326 | ALAPSTMKIKIIAPP | ubiquitination | [1] | | 328 | APSTMKIKIIAPPER | ubiquitination | [1] |
|
Reference | [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML. Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [ PMID: 21139048] |
Functional Description | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
Sequence Annotation | MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 2 2 N-acetylaspartate; in Actin, cytoplasmic
MOD_RES 44 44 Methionine sulfoxide (By similarity).
MOD_RES 73 73 Tele-methylhistidine.
MOD_RES 218 218 Nitrated tyrosine (By similarity). |
Keyword | 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Methylation; Nitration; Nucleotide-binding; Oxidation; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 375 AA |
Protein Sequence | MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS 60
KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT 120
QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL 180
AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY 240
ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS 300
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ 360
EYDESGPSIV HRKCF 375 |
Gene Ontology | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0005829; C:cytosol; TAS:Reactome. GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:AgBase. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0051086; P:chaperone mediated protein folding independent of cofactor; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |