CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004860
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Microtubule-associated protein 2 
Protein Synonyms/Alias
 MAP-2 
Gene Name
 Map2 
Gene Synonyms/Alias
 Mtap2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
328TLPLDTMKNERVSEGubiquitination[1]
577YFETSALKEDMTRSTubiquitination[1]
795SESPFPAKEYYKNGTubiquitination[1]
905FYEGTDDKVRRDLATubiquitination[1]
920DLSLIEVKLAAAGRVubiquitination[1]
1019TSPEKTEKGLSSVPEubiquitination[1]
1035AEVEPTTKADQGLDFubiquitination[1]
1046GLDFAATKAEPSQLDubiquitination[1]
1493PSRKLILKPAIKYTRubiquitination[1]
1698GQVQIVTKKIDLSHVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. 
Sequence Annotation
 REPEAT 1662 1692 Tau/MAP 1.
 REPEAT 1693 1723 Tau/MAP 2.
 REPEAT 1724 1755 Tau/MAP 3.
 REGION 1452 1472 Calmodulin-binding (Potential).
 MOD_RES 608 608 Phosphoserine.
 MOD_RES 626 626 Phosphoserine.
 MOD_RES 655 655 Phosphoserine.
 MOD_RES 730 730 Phosphoserine.
 MOD_RES 737 737 Phosphoserine.
 MOD_RES 746 746 Phosphotyrosine.
 MOD_RES 823 823 Phosphoserine.
 MOD_RES 1161 1161 Phosphoserine.
 MOD_RES 1352 1352 Phosphoserine.
 MOD_RES 1358 1358 Phosphothreonine.
 MOD_RES 1426 1426 Phosphoserine.
 MOD_RES 1445 1445 Phosphothreonine.
 MOD_RES 1485 1485 Phosphoserine.
 MOD_RES 1539 1539 Phosphoserine.
 MOD_RES 1595 1595 Phosphoserine.
 MOD_RES 1598 1598 Phosphothreonine.
 MOD_RES 1599 1599 Phosphothreonine.
 MOD_RES 1606 1606 Phosphothreonine.
 MOD_RES 1609 1609 Phosphothreonine.
 MOD_RES 1612 1612 Phosphoserine.
 MOD_RES 1615 1615 Phosphoserine.
 MOD_RES 1620 1620 Phosphothreonine.
 MOD_RES 1650 1650 Phosphothreonine.
 MOD_RES 1657 1657 Phosphothreonine.
 MOD_RES 1680 1680 Phosphoserine; by MARK1 (By similarity).
 MOD_RES 1711 1711 Phosphoserine (By similarity).
 MOD_RES 1743 1743 Phosphoserine (By similarity).
 MOD_RES 1783 1783 Phosphoserine.
 MOD_RES 1791 1791 Phosphoserine.  
Keyword
 Calmodulin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Microtubule; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1828 AA 
Protein Sequence
MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGAGEG LSRNANGFPY REEEEGAFGE 60
HRSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA EAVAVLKGEQ EKEAQHKDQP 120
AALPLAAEET ANLPPSPPPS PASEQTATVE EDLLTASKME FPEQEKFPSS FAEPLDKGEM 180
EFKMPSKPGE DFEHAALVPD TSKTPQDKKD LQGMEGEKLP PVPFAQTFGT NLEDRKQSTE 240
PSIVMPSIGL SAEPPAPKEP KDWFIEMPTE SKKDEWGLAA PISPGPLTPM REKDVLEDIP 300
RWEGKQFDSP MPSPFHGGSF TLPLDTMKNE RVSEGPRPFA PVFFQSDDKV SLQDPSALAT 360
SKESSKDEEP LKDKADKVAD VSISEVTTLL GNVHSPVVEG YVGENISGEV KVTTDQEKKE 420
TSAPSVQEPT LTETEPQTKL DEKSTVSIEE AVAKKEESFK LRDDKTGVIQ TSTEQSFSKE 480
DQKGQEHTID ELKQDSFPIS LEQAVTDAAM TSKTLGKVTS EPEAVSERRE IQGLFEEKTA 540
DKNKLEGAGS ATIAEVEMPF YEDKSGMSKY FETSALKEDM TRSTELGSDY YELSDSRGSA 600
QESLDTISPK NQHDEKELQA KASQPSPPAQ EAGYSTLAQS YTPDHPSELP EEPSSPQERM 660
FTIDPKVYGE KRDLHSKNKD DLTLSRSLGL GGRSAIEQRS MSINLPMSCL DSIALGFNFG 720
RGHDLSPLAS DILTNTSGSM DEGDDYLPPT TPAVEKMPCF PIESKEEEDK AEQAKVTGGQ 780
TIQVETSSES PFPAKEYYKN GTVMAPDLPE MLDLAGTRSR LASVSADAEV ARRKSVPSEA 840
MLAESSTSLP PVADESPVTV KPDSQLEDMG YCVFNKYTVP LPSPVQDSEN LSGESGSFYE 900
GTDDKVRRDL ATDLSLIEVK LAAAGRVKDE FTAEKEASPP TSADKSRLSR EFDHDRKAND 960
KLDTVLEKSE EHIDSKEHAK ESEEMGGKVE LFGLGITYDQ ASTKELITTK DTSPEKTEKG 1020
LSSVPEVAEV EPTTKADQGL DFAATKAEPS QLDIKVSDFG QMASGMNVDA GKAIELKFEV 1080
AQELTLSSEA PQEADSFMGV ESGHIKEGGK VNETEVKEKV TKPDLVHQEA VDKEESYESS 1140
GEHESLTMES LKPDEGKKET SPETSLIQDE VALKLSVEIP CPPPVSEADL STDEKGEVQM 1200
EFIQLPKEES TETPDIPAIP SDVTQPQPEA IVSEPAEVPS EEEEIEAGGE YDKLLFRSDT 1260
LQISDLLVSE SREEFVETCP GELKGVVESV VTIEDDFITV VQTTTDEGES GSHSVRFAAP 1320
AQPEEERRPR PHDEELEIEM AAEAQAEPKD GSPDAPATPE KEEVAFSEYK TETYDDYKDE 1380
TTIDDSIMDA DSLWVDTQDD DRSILTEQLE TIPKEERAEK DARRPSLEKH RKEKPFKTGR 1440
GRISTPERKV AKKEPSTVSR DEVRRKKAVY KKAELAKKSE VQAHSPSRKL ILKPAIKYTR 1500
PTHLSCVKRK TTAASGDLAQ APGAFKQAKD KVTDGISKSP EKRSSLPRPS SILPPRRGVS 1560
GDREENSFSL NSSISSARRT TRSEPIRRAG KSGTSTPTTP GSTAITPGTP PSYSSRTPGT 1620
PGTPSYPRTP GTPKSGILVP SEKKVAIIRT PPKSPATPKQ LRLINQPLPD LKNVKSKIGS 1680
TDNIKYQPKG GQVQIVTKKI DLSHVTSKCG SLKNIRHRPG GGRVKIESVK LDFKEKAQAK 1740
VGSLDNAHHV PGGGNVKIDS QKLNFREHAK ARVDHGAEII TQSPSRSSVA SPRRLSNVSS 1800
SGSINLLESP QLATLAEDVT AALAKQGL 1828 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0043198; C:dendritic shaft; IDA:MGI.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; TAS:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0034399; C:nuclear periphery; IDA:MGI.
 GO:0005519; F:cytoskeletal regulatory protein binding; TAS:MGI.
 GO:0008017; F:microtubule binding; IDA:MGI.
 GO:0007409; P:axonogenesis; IMP:MGI.
 GO:0071310; P:cellular response to organic substance; IDA:MGI.
 GO:0016358; P:dendrite development; IMP:MGI.
 GO:0001578; P:microtubule bundle formation; IMP:MGI.
 GO:0018107; P:peptidyl-threonine phosphorylation; IDA:MGI. 
Interpro
 IPR027324; MAP2/MAP4/Tau.
 IPR013588; MAP2_projctn.
 IPR001084; Tau/MAP_tubulin-bd_rpt. 
Pfam
 PF08377; MAP2_projctn
 PF00418; Tubulin-binding 
SMART
  
PROSITE
 PS00229; TAU_MAP_1
 PS51491; TAU_MAP_2 
PRINTS