CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013617
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vacuolar protein sorting-associated protein 13A 
Protein Synonyms/Alias
 Chorea-acanthocytosis protein homolog; Chorein 
Gene Name
 Vps13a 
Gene Synonyms/Alias
 Chac; Kiaa0986 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
2221TNRMLQYKADGIHRKubiquitination[1]
2915GLAGAASKITSAMAKubiquitination[1]
2980KPIKGAQKEGAAGFFubiquitination[1]
3144FGKIVNFKTPEDARWubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane (By similarity). 
Sequence Annotation
 REPEAT 212 245 TPR 1.
 REPEAT 373 406 TPR 2.
 REPEAT 1806 1840 TPR 3.
 REPEAT 1999 2034 TPR 4.
 REPEAT 2716 2750 TPR 5.
 REPEAT 2852 2890 TPR 6.
 MOD_RES 2233 2233 Phosphotyrosine.
 MOD_RES 2234 2234 Phosphothreonine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Protein transport; Reference proteome; Repeat; TPR repeat; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3166 AA 
Protein Sequence
MVFESVVVEV LNRFLGDYVV NLDESQLSLG IWKGAVALKN LVIKENALHE LDVPFKVKVG 60
HIGSLKLKIP WKNLYTQPVE AVLEEIFLLI VPSSRIQYDP IKEEKQLMET KQQELKRIEK 120
AKQKVFDKEK PREEKQDTFT EKLVTQIIQN LQVQISSIHI RYEDDITNGD KPLSFGISLQ 180
NISLQTTDQY WIPCLHDNTE KLVRKLIRLD NLFAYWNVNS EMFYLNDYDE SLKALKNGIV 240
NENIVPEGYD FVFRPISASA KLQMNRRSDF DFSDPKINLA VDLHTIAIEF NKPQYFSLME 300
LLESIDMMTQ NQPYRKFKPS VPLHLHAKEW WAYAIHSILE VNVCPSLRMW SWEHIRNHRY 360
KMKRYREFYK KKLTSKKPSP EILMSLEELE KTLDVFNITI ARQQAEVEAK KAGYKIYKEG 420
VKDPEDNAGW FGWLWTWSES NANQQQDVKP GILEEMLTPE EKSLLYEAIG YSETAVDPTL 480
PKTFEALKFF VHLKSMSIVL RENHQKPELL NVVVEGLSTS VVQRPGAQAI KFETKIDSFH 540
ITGLPDDFKK PHLLSSLDDT SLLQITFEIN PLNETVAQRC TIEAEPLEII YDARTVNSIV 600
EFFRPPKDVH LAQLTSVTLT KLEEFRAKTA TGLLYVIETQ KVLDLRINVK ASYVIVPQYG 660
NFSPTSNLLL LDLGHLKVSS KRRSLLPDVR PSEASLEDIM HRAYDSFDIQ LTSIQLLYSR 720
VGDNWKEARK LNVSTQHILI PMHVNVELSK AMVFMDIKMP KFKISGKLPL VSLRISDKKL 780
QGIMELLGSI PKPEPVTDVS APARSFQIQA SALPVSHISQ KLIPLLEQPV TEDDSEEEFF 840
DAPCSPLEEC PQVSCRDKCT RQKKLQKKDC VMNLIQLRMR FEVAEVSIQF YHLVGDCELP 900
VLEMGALGLG TEAEFRTFDL KGSAFLKELW LKCPEYLDEN KKPVYLITTL DNTMEDLLTL 960
EFMKVEKNAP NLNSTYNNVL QLIKVNFSSL DIHLHTEALL NTMNYLNNIL PELREKSASV 1020
SAAEPEDKGD IIKKLALKLP TNEDIITLQL LAELSCLQIF IQDQKQNISE IKIEGLDSEM 1080
IMKPLVTEIN AKLRNIIVLD SDKMAIYKKA LYITGKEVFS FKMISYMDAT AGYAYTDMSV 1140
VDIRVHLTVG CIEVVFITKF LYSILAFIDN FQAVKDALAE ATVQAAEMAA DGVKELARKS 1200
SRFALDVNIK APVVLIPQSP VSQNVFVADF GLITMKNIFV TVTETQSNIP PVIDLITIKL 1260
SKMRLYRSQF RNDTYQEVLD LLLPLNLEVI VERNLSWEWY KEVPCFNIKA QLKPMEFILS 1320
QEDLTTVFQT LHGNIWYGQD LSAPSSANKD PETMTSGVTS PPDHSPATVV TAAVVEVHPQ 1380
ASQAHTMLNV SFQTDYLTMA LYSPGPDEAS FTDVRDPSLE LAEFKLENII SSLKIYTDDS 1440
TVFSFSVKNC ILDDKRSHVM KATPRMIGLT VGFDKKDMVD IKYRKIKTFV VTDAVVQEMY 1500
VCASVEFLMT VAHIFFDAYM TSTALETSVQ TRTTREAPAQ ELGKWEMNIL IKNPEIVFVA 1560
DMTRNDAPAL VITTQCEICC KGEPTSNTVT AAIKDLQVRA CPFLPVKRKG KVTTVLQPCD 1620
LFYQATQLGR DPQMIDISVK SLTLKVSPVI INTIITITSA LYTTKETVPE ENTSNIAHLW 1680
DKKDTKNLKM WFLEESNESE KVVPTNEVMP GGETLNLRID SIFIVLEAGI GHRTVPMLLA 1740
KACFSGESKN WLSLINLHCH LELEVHYYNE MFGVWEPLLE PLEIDQTDDF RPWNLGIKMK 1800
KKAKEAIVES DSEAENYKVP EYKTAISFYS RDQLNITLSK CGLVMLNNLV EAFTEAATGS 1860
SSVFLRDLAP FMIFNSLGLT VSVSPSDSFS VLNVPLAKSY ELKNDESLSM DYVRTKDNDH 1920
FNAMTSLSSK LFFILLTPAN HSVADKIPLT KVGRRLYTVR HRESGVERSI ICQIDTVEGS 1980
KKVTIRSPVQ IKNHFSIPIS VFEGDTLLGI ASPENEFNIP LASYRSSLSL VPEDQDYQLC 2040
EGIDFEEIIK YDGQLLKKKC RSTNPSKKSF VINIVPEKDN LASLSVYSED GWDLPYVLHL 2100
WPPILIRNLL PYKVAYYIEG IENTVVTLSE GHSSQIYNVE MDQAKLHLKL LDYLNHDWKS 2160
EFYIRSSQQD INFINFTCLT EMEKSDLDIA IHMTYNTGQT VVAFHSPYWM VNKTNRMLQY 2220
KADGIHRKHP PNYTKPVLFS FQPNHFFNNN KVQLMVTDSE LSDQFSIDTV GSHGAIRCKG 2280
LKMEYQVGVT INLSSFNITR IVTFIPFYMI KNKSKYHISV AEEGSDKWLS LDLEQSIPFW 2340
PENASNILLI QVERSEDPPK RIYFNKQDNC ILLRLNNELG GIIAEVNLAE HSTVITFSDY 2400
HDGAATFLLI NHTKSDPVQY NQSSLGEIED SLPPGKAVYY TWADPVGSRK LKWSCGQSYG 2460
EVTHKDDMMT PISVGKKTIY LVSFFEGLQR IILFTEDPRV FKVTYESEKA ELAELEVVLA 2520
LQDVGISLVN NYTKQEVAYI GITSSDVVWE AKPKKKARWK PMSVKHTEKL EKEFREYTEA 2580
SPLEDKVVEL DNIPVRLTPS GNDMKILQPH VIPVRRNYLP ALKVEYNTSA HQSSFRIQIY 2640
RIQIQNQIHG AIFPFVFYPI KPPRSVTMDS APKPFTDVSI VMRSAGHSQI SRIKYFKVLI 2700
QEMDLSLDLG FVYALADLVT KAEVTEKTEV EHFHKDVEAF EQEYEVVSSV DQSQVNLFEY 2760
FHISPIKLHL SVSLSSGRDE AKDSEQHGGL IPVHSLNLLL KSIGATLTDV QDVVFKLAFF 2820
ELNYQFHTTS ELQSEVIRHY SKQAIKQMYV LILGLDVLGN PFGLIREFSE GVEAFFYEPY 2880
QGAIQGPEEF VEGMALGLKA LVGGAVGGLA GAASKITSAM AKGVAAMTMD EDYQQKRREA 2940
MNKQPAGLRE GITRGGKGLV SGFVSGITGI VTKPIKGAQK EGAAGFFKGV GKGLVGAVTR 3000
PTGGIIDMAS STFQGIKRAT ETSEVESLRP PRFFNEDGVI RPYRLRDGSG NQMLQVMENG 3060
RFAKYKYFTH VMINKTDMFM ITRRGVLFVT KGTFGQLTCE WQYTFDEFTK EPFIVHGRRL 3120
RIEAKERVKS VFHAKEFGKI VNFKTPEDAR WILTKLEEAR EPSPRL 3166 
Gene Ontology
 GO:0031045; C:dense core granule; IDA:MGI.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0007399; P:nervous system development; IMP:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0035176; P:social behavior; IMP:MGI. 
Interpro
 IPR015412; Autophagy-rel_C.
 IPR026847; VPS13.
 IPR026854; VPS13A_N.
 IPR009543; VPSAP_dom. 
Pfam
 PF09333; ATG_C
 PF12624; Chorein_N
 PF06650; DUF1162 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS