UniProt Accession

 TBC19_HUMAN; Q8N5T2; Q9NUX1 

Genbank Protein ID

 AK001944; AC093807; AC107390; BC031642 

Genbank Nucleotide ID

 BAA91992.1; AAH31642.1 

Protein Name

 TBC1 domain family member 19 

Protein Synonyms/Alias

  

Gene Name

 TBC1D19 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
135	EQKELLNKWNEMGTD	ubiquitination	[1]
234	EHVRIGQKVLAEQDS	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May act as a GTPase-activating protein for Rab family protein(s). 

Sequence Annotation

 DOMAIN 251 472 Rab-GAP TBC.  

Keyword

 Complete proteome; GTPase activation; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 526 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 

Interpro

 IPR000195; Rab-GTPase-TBC_dom. 

Pfam

 PF00566; RabGAP-TBC 

SMART

 SM00164; TBC 

PROSITE

 PS50086; TBC_RABGAP 

PRINTS