UniProt Accession

 ASGR1_MOUSE; P34927; Q64363; Q91Y84 

Genbank Protein ID

 D13517; U09362; U08372; AF182811; AK132959; AL596185; CH466596; BC022106 

Genbank Nucleotide ID

 BAA02734.1; AAB60441.1; AAB60440.1; AAF29495.1; BAE21442.1; CAI35175.1; EDL12529.1; AAH22106.1 

Protein Name

 Asialoglycoprotein receptor 1 

Protein Synonyms/Alias

 ASGP-R 1; ASGPR 1; Hepatic lectin 1; HL-1; mHL-1 

Gene Name

 Asgr1 

Gene Synonyms/Alias

 Asgr-1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
3	*****MTKDYQDFQH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. 

Sequence Annotation

 DOMAIN 160 277 C-type lectin.
 MOTIF 5 8 Endocytosis signal (Potential).
 METAL 190 190 Calcium 1; via carbonyl oxygen (By
 METAL 196 196 Calcium 1 (By similarity).
 METAL 215 215 Calcium 2 (By similarity).
 METAL 239 239 Calcium 3 (By similarity).
 METAL 241 241 Calcium 3 (By similarity).
 METAL 252 252 Calcium 2; via carbonyl oxygen (By
 METAL 252 252 Calcium 3 (By similarity).
 METAL 253 253 Calcium 2 (By similarity).
 METAL 264 264 Calcium 3 (By similarity).
 METAL 265 265 Calcium 3 (By similarity).
 METAL 277 277 Calcium 1 (By similarity).
 BINDING 239 239 Carbohydrate (By similarity).
 BINDING 243 243 Carbohydrate (By similarity).
 BINDING 252 252 Carbohydrate (By similarity).
 LIPID 35 35 S-palmitoyl cysteine (By similarity).
 CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
 CARBOHYD 78 78 N-linked (GlcNAc...) (Potential).
 CARBOHYD 146 146 N-linked (GlcNAc...) (Potential).
 DISULFID 153 164 By similarity.
 DISULFID 181 276 By similarity.
 DISULFID 254 268 By similarity.  

Keyword

 Calcium; Coiled coil; Complete proteome; Disulfide bond; Endocytosis; Glycoprotein; Lectin; Lipoprotein; Membrane; Metal-binding; Palmitate; Phosphoprotein; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004873; F:asialoglycoprotein receptor activity; IEA:Compara.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0031668; P:cellular response to extracellular stimulus; IDA:MGI. 

Interpro

 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR018378; C-type_lectin_CS.
 IPR016187; C-type_lectin_fold.
 IPR005640; Lectin_N. 

Pfam

 PF00059; Lectin_C
 PF03954; Lectin_N 

SMART

 SM00034; CLECT 

PROSITE

 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2 

PRINTS