CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002180
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutathione S-transferase alpha-3 
Protein Synonyms/Alias
 GST 2-2; GST A3-3; GST AA; Glutathione S-transferase Yc-1; GST Yc1 
Gene Name
 Gsta3 
Gene Synonyms/Alias
 Gstyc1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
195VSNLPTVKKFLQPGSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has substantial activity toward aflatoxin B1-8,9-epoxide. 
Sequence Annotation
 DOMAIN 3 83 GST N-terminal.
 DOMAIN 85 207 GST C-terminal.
 REGION 54 55 Glutathione binding (By similarity).
 REGION 67 68 Glutathione binding (By similarity).
 BINDING 9 9 Glutathione (By similarity).
 BINDING 45 45 Glutathione (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 221 AA 
Protein Sequence
MPGKPVLHYF DGRGRMEPIR WLLAAAGVEF EEQFLKTRDD LARLRNDGSL MFQQVPMVEI 60
DGMKLVQTRA ILNYIATKYN LYGKDMKERA LIDMYAEGVA DLDEIVLHYP YIPPGEKEAS 120
LAKIKDKARN RYFPAFEKVL KSHGQDYLVG NRLSRADVYL VQVLYHVEEL DPSALANFPL 180
LKALRTRVSN LPTVKKFLQP GSQRKPLEDE KCVESAVKIF S 221 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005640; C:nuclear outer membrane; IDA:RGD.
 GO:0008144; F:drug binding; IDA:RGD.
 GO:0043295; F:glutathione binding; IDA:RGD.
 GO:0004364; F:glutathione transferase activity; IDA:RGD.
 GO:0007568; P:aging; IEP:RGD.
 GO:0042493; P:response to drug; NAS:RGD.
 GO:0031667; P:response to nutrient levels; IEP:RGD.
 GO:0042178; P:xenobiotic catabolic process; IDA:RGD. 
Interpro
 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR003080; GST_alpha.
 IPR004046; GST_C.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF00043; GST_C
 PF02798; GST_N 
SMART
  
PROSITE
 PS50405; GST_CTER
 PS50404; GST_NTER 
PRINTS
 PR01266; GSTRNSFRASEA.