CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002270
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bis(5'-nucleosyl)-tetraphosphatase [symmetrical] 
Protein Synonyms/Alias
 Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase 
Gene Name
 apaH 
Gene Synonyms/Alias
 b0049; JW0048 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
29KVEFTPGKDTLWLTGacetylation[1]
114LLQIDEEKKLVMAHAacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618
Functional Description
 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP. 
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 280 AA 
Protein Sequence
MATYLIGDVH GCYDELIALL HKVEFTPGKD TLWLTGDLVA RGPGSLDVLR YVKSLGDSVR 60
LVLGNHDLHL LAVFAGISRN KPKDRLTPLL EAPDADELLN WLRRQPLLQI DEEKKLVMAH 120
AGITPQWDLQ TAKECARDVE AVLSSDSYPF FLDAMYGDMP NNWSPELRGL GRLRFITNAF 180
TRMRFCFPNG QLDMYSKESP EEAPAPLKPW FAIPGPVAEE YSIAFGHWAS LEGKGTPEGI 240
YALDTGCCWG GTLTCLRWED KQYFVQPSNR HKDLGEAAAS 280 
Gene Ontology
 GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; IDA:EcoliWiki.
 GO:0015949; P:nucleobase-containing small molecule interconversion; IMP:EcoliWiki. 
Interpro
 IPR004617; ApaH.
 IPR004843; Metallo_PEstase_dom. 
Pfam
 PF00149; Metallophos 
SMART
  
PROSITE
  
PRINTS