| Tag | Content |
|---|
| CPLM ID | CPLM-013056 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase BRE1B |
Protein Synonyms/Alias | BRE1-B; RING finger protein 40 |
Gene Name | Rnf40 |
Gene Synonyms/Alias | Bre1b; Kiaa0661 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 20 | GGSGPPEKKMNREEK | acetylation | [1] | | 517 | EVQAEIGKLRAQASG | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes (By similarity). |
Sequence Annotation | ZN_FING 948 987 RING-type. |
Keyword | Chromatin regulator; Coiled coil; Complete proteome; Ligase; Metal-binding; Nucleus; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1001 AA |
Protein Sequence | MSGLSNKRAA GDGGSGPPEK KMNREEKTTT TLIEPIRLGG ISSTEEMDSK VLQFKNKKLA 60
ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ LDETVEALLQ CYENQRELSS 120
GTEVPGCQEG LTRDVIPRPD PGTSDLREPL PVQFRAPLSE PALAFVVALG ASSCEEVELQ 180
LQGRMEFSKA AVSRVVEASD RLQRQVEELC QRVYSRGDSE APGEVARVRT RELGRENRRL 240
QDLATQLQEK HHRISLEYSE LQDKVTSTET KVLEMETTVE DLQWDIEKLR KREQKLNKHL 300
AEALEQLNSG YYVSGSSTGF QGGQITLSMQ KFEMLNAELE ENQELANSRM AELEKLQAEL 360
QGAVRTNERL KVALRSLPEE VVRETGEYRM LQAQFSLLYN ESLQVKTQLD EARGLLLASK 420
NSHLRHIEHM ESDELGLQKK LRTEVIQLED TLAQVRKEYE MLRIEFEQNL AANEQAGPIN 480
REMRHLISSL QNHNHQLKGD AQRYKRKLRE VQAEIGKLRA QASGSSHCIP TLSHPDDPGL 540
NALAPGKEDS GPGPGGTPDC KKEMALLAGA TSATSSIKKE ELVSSEDDAQ ALTPVTQGLP 600
SRGREPEARP KRELREREGP SLGPPPAAST LSRADREKAK VEEAKRKESE LLKGLRAELK 660
KAQESQKEMK LLLDMYKSAP KEQRDKVQLM AAERKAKAEV DELRSRIREL EERDRRESKK 720
IADEDALRRI RQAEEQIEHL QRKLGATKQE EEALLSEMDV TGQAFEDMQE QNGRLLQQLR 780
EKDDANFKLM SERIKANQIH KLLREEKDEL GEQVLGLKSQ VDAQLLTVQK LEEKERALQG 840
SLGGVEKELT LRSQALELNK RKAVEAAQLA EDLKVQLEHV QTRLREIQPC LAESRAAREK 900
ESFNLKRAQE DISRLRRKLE KQRKVEVYAD ADEILQEEIK EYKARLTCPC CNTRKKDAVL 960
TKCFHVFCFE CVRGRYEARQ RKCPKCNAAF GAHDFHRVYI S 1001 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:Compara. GO:0033503; C:HULC complex; ISS:UniProtKB. GO:0043005; C:neuron projection; IEA:Compara. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:Compara. GO:0004842; F:ubiquitin-protein ligase activity; IEA:Compara. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0033523; P:histone H2B ubiquitination; IEA:Compara. GO:0010390; P:histone monoubiquitination; IEA:Compara. GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Compara. |
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PROSITE | |
PRINTS | |