CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039016
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA polymerase 
Protein Synonyms/Alias
  
Gene Name
 Pola1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
199PKAIPSGKPASLVLRacetylation[1]
208ASLVLRNKPLLTPIPacetylation[1]
1067YITKQELKGLDIVRRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA replication; DNA-binding; DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1453 AA 
Protein Sequence
SDVSGSGSFV ASRARREKKS KKGRQEALER LKKAKAGEKY KYEVEDLTSV YEEVDEEQYS 60
KLVQARQDDD WIVDDDGIGY VEDGREIFDD DLEDDALDTC GEGSDGKAHR KDRKDVKKPS 120
VTKPNNIKAM FIASAGKKTT DKTVDLSKDD LLGDILQDLN TETPQIAPPP VLIPKKKRST 180
GALPNPFSVD TPKAIPSGKP ASLVLRNKPL LTPIPLKHAE FAGELAQPEC PEDEQESGVI 240
EFEDGDFDEP MDTEEVDEEE PVTAKIWDQE SEPVEGVKHE ADPETGTTSF LDSFLPDVSC 300
WDIDQKDENS FLLQEVQVDS NHLPLVKGAD DEQVFQFYWL DAYEDAYNQP GVVFLFGKVW 360
VESAKTHVSC CVMVKNIERT LYFLPREMKI DLNTGKETAT PITMKDVYEE FDSKISAKYK 420
IMKFKSKIVE KNYAFEIPDV PEKSEYLEVR YSVSQRKMRK GLLNPTVHEL YCLSSRHLQI 480
TLRNIKLLMC CIYSFSELLN QPISWCKFEA MALKPDLVNV IKDVSPPPLV VMSFSMKTMQ 540
NVKNHQHEII AMAALVHHNF PLDKAPPKPP FQTHFCVVSK PKDCIFPCAF KEVIKKKNME 600
VEVAATERTL LGFFLAKVHK LDPDILVGHN ICGFELEVLL QRINECKVPF WSKIGRLRRS 660
NMPKLGSRSG FGERNATCGR MICDVEISAK ELIHCKSYHL SELVQQILKT ERIVIPTENI 720
RNMYSEPSHL LYLLEHIWKD ARFILQIMCE LNVLPLALQI TNIAGNIMSR TLMGGRSERN 780
EFLLLHAFYE NNYIVPDKQI FRKPQQKPGD EDEEIDGDTN KYKKGRKKAA YAGGLVLDPK 840
VGFYDKFILL LDFNSLYPSI IQEFNICFTT VQRVASETLK ATEDEEQEQI PELPDPNLDM 900
GILPREIRKL VERRKQVKQL MKQQDLNPDL VLQYDIRQKA LKLTANSMYG CLGFSYSRFY 960
AKPLAALVTY KGREILMHTK EMVQKMNLEV IYGDTDSIMI NTNSTNLEEV FKLGNKVKNE 1020
VNKLYKLLEI DIDGVFKSLL LLKKKKYAAL VVEPTSDGNY ITKQELKGLD IVRRDWCDLA 1080
KDTGNFVIGQ ILSDQSRDTI VENIQKRLIE IGENVLNGSV PVSQFEINKA LTKDPQDYPD 1140
KKSLPHVHVA LWINSQGGRK VKAGDTVSYV ICQDGSNLPA TQRAYAPEQL QKQDNLAIDT 1200
QYYLAQQIHP VVARICEPID GIDAVLIALW LGLDSTQFRV HQYHKDEEND ALLGGPAQLT 1260
DEEKYKDCEK FKCLCPSCGT ENIYDNVFEG SGMDMEPSLN RCSNIDCKAS PATFMVQLSN 1320
KLIMDIRRCI KKYYDGWLMC EEPTCRNRIR RLPLHFSRNG PLCPACMKAV LRPEYSDKSL 1380
YTQLCFYRYI FDADCALEKL PEHEKDKLKK QFFTPRVLQD YRKVKNIAEH FLSWSGYSEV 1440
NLSKLFANYA GKN 1453 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
 GO:0001882; F:nucleoside binding; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 
Interpro
 IPR006172; DNA-dir_DNA_pol_B.
 IPR017964; DNA-dir_DNA_pol_B_CS.
 IPR006133; DNA-dir_DNA_pol_B_exonuc.
 IPR006134; DNA-dir_DNA_pol_B_multi_dom.
 IPR004578; DNA-dir_DNA_pol_B_pol2.
 IPR024647; DNA_pol_a_cat_su_N.
 IPR023211; DNA_pol_palm_dom.
 IPR012337; RNaseH-like_dom.
 IPR015088; Znf_DNA-dir_DNA_pol_B_alpha. 
Pfam
 PF12254; DNA_pol_alpha_N
 PF00136; DNA_pol_B
 PF03104; DNA_pol_B_exo1
 PF08996; zf-DNA_Pol 
SMART
 SM00486; POLBc 
PROSITE
 PS00116; DNA_POLYMERASE_B 
PRINTS
 PR00106; DNAPOLB.