| Tag | Content |
|---|
| CPLM ID | CPLM-017856 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable E3 ubiquitin-protein ligase DTX2 |
Protein Synonyms/Alias | Protein deltex-2; Deltex2; mDTX2 |
Gene Name | Dtx2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 550 | RKVLELLKVAWKRRL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). |
Sequence Annotation | DOMAIN 7 97 WWE 1.
DOMAIN 98 174 WWE 2.
ZN_FING 409 470 RING-type.
MOD_RES 248 248 N6-acetyllysine (By similarity). |
Keyword | 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Ligase; Metal-binding; Notch signaling pathway; Nucleus; Reference proteome; Repeat; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 619 AA |
Protein Sequence | MAMAPSSSLP QVYPSHVVVA VWEWQDGLGI WHPYSATVCS FIEQHFVRQR GQHFGLGSLA 60
HSIPLGQADP SLAPYIIDLP SWTQFRQNTG TMRSVRRHLF SQNSAPGQGI VWEWLGDDGS 120
WVAYEARICD YLEQQVARGI QVVDLAPLGY NYTVNYATLT QTNKTSSFCR SVRRQVGPVY 180
PVTSDIAVPR QMGLICFCQQ CLHGSGTGPV SGRYRHSMTN LPAYPAPQAP HRTTTVSGAH 240
QAFAPYNKPS LSGARSAPRL NTTNPWAAAP PVAGNQSLFH SSLSHLGPQL LPSGPSTSSG 300
ASASFPSGPS SSSPGSAPTT VPVQMPKASR VQQALAGMTS VLSAIGLPVC LSRAPRPTGP 360
PASRPASKSH SSVKRLRKMS VKEGAPKPEP EQVIRKYTEE LKVAPEEDCI ICMEKLAVAS 420
GYSDMTDSKA LGPMVVGRLT KCSHAFHLLC LLAMYCNGNK DGSLQCPSCK TIYGEKTGTQ 480
PWGKMEVFRF QMSLPGHEDC GTILIVYNIP HGIQGPEHPS PGKPFTARGF PRQCYLPDSP 540
QGRKVLELLK VAWKRRLIFT VGTSSTTGET DTVVWNEIHH KTEMDRNVTG HGYPDPNYLQ 600
NVLAELAAQG VTEDCLEQQ 619 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |