UniProt Accession

 NSRR_ECOLI; P0AF63; P21498; P72442; Q2M6C7 

Genbank Protein ID

 J04199; U14003; U00096; AP009048 

Genbank Nucleotide ID

 AAA97074.1; AAC77135.1; BAE78179.1 

Protein Name

 HTH-type transcriptional repressor NsrR 

Protein Synonyms/Alias

  

Gene Name

 nsrR 

Gene Synonyms/Alias

 yjeB; b4178; JW4136 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
44	VSRNHMVKIINQLSR	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress, such as ytfE, hmpA and ygbA. May require iron for activity. Does not regulates its own transcription. 

Sequence Annotation

 DOMAIN 2 129 HTH rrf2-type.
 DNA_BIND 28 51 H-T-H motif (By similarity).
 METAL 91 91 Iron-sulfur (2Fe-2S) (Potential).
 METAL 96 96 Iron-sulfur (2Fe-2S) (Potential).
 METAL 102 102 Iron-sulfur (2Fe-2S) (Potential).  

Keyword

 2Fe-2S; Complete proteome; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 141 AA 

Protein Sequence

Gene Ontology

 GO:0032993; C:protein-DNA complex; IDA:EcoCyc.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IDA:EcoCyc.
 GO:0003690; F:double-stranded DNA binding; IEA:HAMAP.
 GO:0005506; F:iron ion binding; IEA:HAMAP.
 GO:0051536; F:iron-sulfur cluster binding; IDA:EcoCyc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:HAMAP.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000944; Tscrpt_reg_Rrf2-like.
 IPR023761; Tscrpt_rep_HTH_NsrR.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF02082; Rrf2 

SMART

  

PROSITE

 PS01332; HTH_RRF2_1
 PS51197; HTH_RRF2_2 

PRINTS