CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006530
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription factor SOX-6 
Protein Synonyms/Alias
  
Gene Name
 SOX6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
404TVSPTGIKNEKRGTSsumoylation[1]
417TSPVTQVKDEAAAQPsumoylation[1]
Reference
 [1] Repression of SOX6 transcriptional activity by SUMO modification.
 Fernández-Lloris R, Osses N, Jaffray E, Shen LN, Vaughan OA, Girwood D, Bartrons R, Rosa JL, Hay RT, Ventura F.
 FEBS Lett. 2006 Feb 20;580(5):1215-21. [PMID: 16442531] 
Functional Description
 Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation. 
Sequence Annotation
 DNA_BIND 621 689 HMG box.
 MOD_RES 126 126 Phosphoserine (By similarity).
 CROSSLNK 404 404 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 417 417 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Activator; Alternative splicing; Coiled coil; Complete proteome; Developmental protein; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 828 AA 
Protein Sequence
MSSKQATSPF ACAADGEDAM TQDLTSREKE EGSDQHVASH LPLHPIMHNK PHSEELPTLV 60
STIQQDADWD SVLSSQQRME SENNKLCSLY SFRNTSTSPH KPDEGSRDRE IMTSVTFGTP 120
ERRKGSLADV VDTLKQKKLE EMTRTEQEDS SCMEKLLSKD WKEKMERLNT SELLGEIKGT 180
PESLAEKERQ LSTMITQLIS LREQLLAAHD EQKKLAASQI EKQRQQMDLA RQQQEQIARQ 240
QQQLLQQQHK INLLQQQIQV QGHMPPLMIP IFPHDQRTLA AAAAAQQGFL FPPGITYKPG 300
DNYPVQFIPS TMAAAAASGL SPLQLQKGHV SHPQINQRLK GLSDRFGRNL DTFEHGGGHS 360
YNHKQIEQLY AAQLASMQVS PGAKMPSTPQ PPNTAGTVSP TGIKNEKRGT SPVTQVKDEA 420
AAQPLNLSSR PKTAEPVKSP TSPTQNLFPA SKTSPVNLPN KSSIPSPIGG SLGRGSSLDI 480
LSSLNSPALF GDQDTVMKAI QEARKMREQI QREQQQQQPH GVDGKLSSIN NMGLNSCRNE 540
KERTRFENLG PQLTGKSNED GKLGPGVIDL TRPEDAEGSK AMNGSAAKLQ QYYCWPTGGA 600
TVAEARVYRD ARGRASSEPH IKRPMNAFMV WAKDERRKIL QAFPDMHNSN ISKILGSRWK 660
SMSNQEKQPY YEEQARLSKI HLEKYPNYKY KPRPKRTCIV DGKKLRIGEY KQLMRSRRQE 720
MRQFFTVGQQ PQIPITTGTG VVYPGAITMA TTTPSPQMTS DCSSTSASPE PSLPVIQSTY 780
GMKTDGGSLA GNEMINGEDE MEMYDDYEDD PKSDYSSENE APEAVSAN 828 
Gene Ontology
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0035051; P:cardiocyte differentiation; IEA:Compara.
 GO:0051216; P:cartilage development; IEA:Compara.
 GO:0000902; P:cell morphogenesis; IEA:Compara.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:UniProtKB.
 GO:0048821; P:erythrocyte development; IEA:Compara.
 GO:0016458; P:gene silencing; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0042692; P:muscle cell differentiation; IEA:Compara.
 GO:0007517; P:muscle organ development; NAS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0021778; P:oligodendrocyte cell fate specification; IEA:Compara.
 GO:0061036; P:positive regulation of cartilage development; IDA:UniProtKB.
 GO:0032332; P:positive regulation of chondrocyte differentiation; IDA:UniProtKB.
 GO:2000741; P:positive regulation of mesenchymal stem cell differentiation; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR009071; HMG_box_dom.
 IPR027153; Sox-6. 
Pfam
 PF00505; HMG_box 
SMART
 SM00398; HMG 
PROSITE
 PS50118; HMG_BOX_2 
PRINTS