CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040129
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Runt-related transcription factor 2 
Protein Synonyms/Alias
  
Gene Name
 RUNX2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
306RQKLDDSKPSLFSDRacetylation[1]
306RQKLDDSKPSLFSDRubiquitination[2]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 567 AA 
Protein Sequence
MLHSPHKQPQ NHKCGANFLQ EDSKKSLVFK WLISAGHYQP PRPTESFKAA SSIYNRGYKF 60
YLKKKGGTMA SNSLFSTVTP CQQNFFWDPS TSRRFSPPSS SLQPGKMSDV SPVVAAQQQQ 120
QQQQQQQQQQ QQQQQQQQQE AAAAAAAAAA AAAAAAAVPR LRPPHDNRTM VEIIADHPAE 180
LVRTDSPNFL CSVLPSHWRC NKTLPVAFKV VALGEVPDGT VVTVMAGNDE NYSAELRNAS 240
AVMKNQVARF NDLRFVGRSG RGKSFTLTIT VFTNPPQVAT YHRAIKVTVD GPREPRRHRQ 300
KLDDSKPSLF SDRLSDLGRI PHPSMRVGVP PQNPRPSLNS APSPFNPQGQ SQITDPRQAQ 360
SSPPWSYDQS YPSYLSQMTS PSIHSTTPLS STRGTGLPAI TDVPRRISGA SELGPFSDPR 420
QFPSISSLTE SRFSNPRMHY PATFTYTPPV TSGMSLGMSA TTHYHTYLPP PYPGSSQSQS 480
GPFQTSSTPY LYYGTSSGSY QFPMVPGGDR SPSRMLPPCT TTSNGSTLLN PNLPNQNDGV 540
DADGSHSSSP TVLNSSGRMD ESVWRPY 567 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. 
Interpro
 IPR000040; AML1_Runt.
 IPR008967; p53-like_TF_DNA-bd.
 IPR012346; p53/RUNT-type_TF_DNA-bd.
 IPR013524; Runt_dom.
 IPR027384; Runx_central_dom.
 IPR013711; RunxI_C_dom. 
Pfam
 PF00853; Runt
 PF08504; RunxI 
SMART
  
PROSITE
 PS51062; RUNT 
PRINTS
 PR00967; ONCOGENEAML1.