CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017006
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Beta-galactosidase-1-like protein 2 
Protein Synonyms/Alias
  
Gene Name
 GLB1L2 
Gene Synonyms/Alias
 MSTP014; UNQ210/PRO236 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
86RDRLLKMKACGLNTLubiquitination[1]
165MRLRTTYKGFTEAVDubiquitination[2]
188RVVPLQYKRGGPIIAubiquitination[1]
216PAYMPYVKKALEDRGubiquitination[2]
234LLLTSDNKDGLSKGIubiquitination[2]
357EAGDYTAKYMKLRDFubiquitination[2]
502ENIDDQRKGLIGNLYubiquitination[1, 2]
516YLNDSPLKNFRIYSLubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
 ACT_SITE 201 201 Proton donor (By similarity).
 ACT_SITE 277 277 Nucleophile (By similarity).  
Keyword
 Complete proteome; Glycosidase; Hydrolase; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 636 AA 
Protein Sequence
MTTWSLRRRP ARTLGLLLLV VLGFLVLRRL DWSTLVPLRL RHRQLGLQAK GWNFMLEDST 60
FWIFGGSIHY FRVPREYWRD RLLKMKACGL NTLTTYVPWN LHEPERGKFD FSGNLDLEAF 120
VLMAAEIGLW VILRPGPYIC SEMDLGGLPS WLLQDPGMRL RTTYKGFTEA VDLYFDHLMS 180
RVVPLQYKRG GPIIAVQVEN EYGSYNKDPA YMPYVKKALE DRGIVELLLT SDNKDGLSKG 240
IVQGVLATIN LQSTHELQLL TTFLFNVQGT QPKMVMEYWT GWFDSWGGPH NILDSSEVLK 300
TVSAIVDAGS SINLYMFHGG TNFGFMNGAM HFHDYKSDVT SYDYDAVLTE AGDYTAKYMK 360
LRDFFGSISG IPLPPPPDLL PKMPYEPLTP VLYLSLWDAL KYLGEPIKSE KPINMENLPV 420
NGGNGQSFGY ILYETSITSS GILSGHVHDR GQVFVNTVSI GFLDYKTTKI AVPLIQGYTV 480
LRILVENRGR VNYGENIDDQ RKGLIGNLYL NDSPLKNFRI YSLDMKKSFF QRFGLDKWSS 540
LPETPTLPAF FLGSLSISST PCDTFLKLEG WEKGVVFING QNLGRYWNIG PQKTLYLPGP 600
WLSSGINQVI VFEETMAGPA LQFTETPHLG RNQYIK 636 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0004565; F:beta-galactosidase activity; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. 
Interpro
 IPR026283; B-gal_1-like.
 IPR008979; Galactose-bd-like.
 IPR019801; Glyco_hydro_35_CS.
 IPR013781; Glyco_hydro_catalytic_dom.
 IPR001944; Glycoside_Hdrlase_35.
 IPR017853; Glycoside_hydrolase_SF. 
Pfam
 PF01301; Glyco_hydro_35 
SMART
  
PROSITE
 PS01182; GLYCOSYL_HYDROL_F35 
PRINTS
 PR00742; GLHYDRLASE35.