CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042337
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Disabled homolog 2-interacting protein 
Protein Synonyms/Alias
  
Gene Name
 DAB2IP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1045KIIDAQEKRIASLDAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1069 AA 
Protein Sequence
SQPKLDRNHS FRHILPGFRS AAAAAADNER SHLMPRLKES RSHESLLSPS SAVEALDLSM 60
EEEVVIKPVH SSILGQDYCF EVTTSSGSKC FSCRSAAERD KWMENLRRAV HPNKDNSRRV 120
EHILKLWVIE AKDLPAKKKY LCELCLDDVL YARTTGKLKT DNVFWGEHFE FHNLPPLRTV 180
TVHLYRETDK KKKKERNSYL GLVSLPAASV AGRQFVEKWY PVVTPNPKGG KGPGPMIRIK 240
ARYQTITILP MEMYKEFAEH ITNHYLGLCA ALEPILSAKT KEEMASALVH ILQSTGKVKD 300
FLTDLMMSEV DRCGDNEHLI FRENTLATKA IEEYLKLVGQ KYLQDALGEF IKALYESDEN 360
CEVDPSKCSA ADLPEHQGNL KMCCELAFCK IINSYCVFPR ELKEVFASWR QECSSRGRPD 420
ISERLISASL FLRFLCPAIM SPSLFNLLQE YPDDRTARTL TLIAKVTQNL ANFAKFGSKE 480
EYMSFMNQFL EHEWTNMQRF LLEISNPETL SNTAGFEGYI DLGRELSSLH SLLWEAVSQL 540
EQSIVSKLGP LPRILRDVHT ALSTPGSGQL PGTNDLASTP GSGSSSISAG LQKMVIENDL 600
SGLIDFTRLP SPTPENKDLF FVTRSSGVQP SPARSSSYSE ANEPDLQMAN GGKSLSMVDL 660
QDARTLDGEA GSPAGPDVLP TDGQAAAAQL VAGWPARATP VNLAGLATVR RAGQTPTTPG 720
TSEGAPGRPQ LLAPLSFQNP VYQMAAGLPL SPRGLGDSGS EGHSSLSSHS NSEELAAAAK 780
LGSFSTAAEE LARRPGELAR RQMSLTEKGG QPTVPRQNSA GPQRRIDQPP PPPPPPPPAP 840
RGRTPPNLLS TLQYPRPSSG TLASASPDWV GPSTRLRQQS SSSKGDSPEL KPRAVHKQGP 900
SPVSPNALDR TAAWLLTMNA QLLEDEGLGP DPPHRDRLRS KDELSQAEKD LAVLQDKLRI 960
STKKLEEYET LFKCQEETTQ KLVLEYQARL EEGEERLRRQ QEDKDIQMKG IISRLMSVEE 1020
ELKKDHAEMQ AAVDSKQKII DAQEKRIASL DAANARLMSA LTQLKESMH 1069 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005099; F:Ras GTPase activator activity; IEA:Compara.
 GO:0071364; P:cellular response to epidermal growth factor stimulus; IEA:Compara.
 GO:0071356; P:cellular response to tumor necrosis factor; IEA:Compara.
 GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Compara.
 GO:0035414; P:negative regulation of catenin import into nucleus; IEA:Compara.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IEA:Compara.
 GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Compara.
 GO:0071901; P:negative regulation of protein serine/threonine kinase activity; IEA:Compara.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0043507; P:positive regulation of JUN kinase activity; IEA:Compara.
 GO:0032320; P:positive regulation of Ras GTPase activity; IEA:GOC. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR021887; DUF3498.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR001936; RasGAP.
 IPR023152; RasGAP_CS.
 IPR008936; Rho_GTPase_activation_prot. 
Pfam
 PF00168; C2
 PF12004; DUF3498
 PF00616; RasGAP 
SMART
 SM00239; C2
 SM00233; PH
 SM00323; RasGAP 
PROSITE
 PS50003; PH_DOMAIN
 PS00509; RAS_GTPASE_ACTIV_1
 PS50018; RAS_GTPASE_ACTIV_2 
PRINTS