CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014521
UniProt Accession
Genbank Protein ID
 L33413 
Genbank Nucleotide ID
Protein Name
 Advanced glycosylation end product-specific receptor 
Protein Synonyms/Alias
 Receptor for advanced glycosylation end products 
Gene Name
 Ager 
Gene Synonyms/Alias
 Rage 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
122RVYQIPGKPEIVNPAacetylation[1]
173DGKGTVVKEETRRHPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. 
Sequence Annotation
 DOMAIN 23 109 Ig-like V-type.
 DOMAIN 123 219 Ig-like C2-type 1.
 DOMAIN 233 315 Ig-like C2-type 2.
 CARBOHYD 25 25 N-linked (GlcNAc...) (Potential).
 CARBOHYD 80 80 N-linked (GlcNAc...) (Potential).
 DISULFID 38 98 Potential.
 DISULFID 143 206 Potential.
 DISULFID 257 299 Potential.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Inflammatory response; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 402 AA 
Protein Sequence
MPTGTVARAW VLVLALWGAV AGGQNITARI GEPLMLSCKG APKKPTQKLE WKLNTGRTEA 60
WKVLSPQGDP WDSVARILPN GSLLLPAIGI VDEGTFRCRA TNRLGKEVKS NYRVRVYQIP 120
GKPEIVNPAS ELTANVPNKV GTCVSEGSYP AGTLSWHLDG KPLIPDGKGT VVKEETRRHP 180
ETGLFTLRSE LTVTPAQGGT TPTYSCSFSL GLPRRRPLNT APIQPRVREP LPPEGIQLLV 240
EPEGGTVAPG GTVTLTCAIS AQPPPQIHWI KDGTPLPLAP SPVLLLPEVG HEDEGIYSCV 300
ATHPSHGPQE SPPVNIRVTE TGDEGQAAGS VDGSGLGTLA LALGILGGLG IAALLIGAIL 360
WRKRQPRLEE RKAPESQEDE EERAELNQSE EAEMPENGAG GP 402 
Gene Ontology
 GO:0030424; C:axon; IDA:RGD.
 GO:0009925; C:basal plasma membrane; IDA:RGD.
 GO:0009986; C:cell surface; IDA:RGD.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0050785; F:advanced glycation end-product receptor activity; IMP:RGD.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0055074; P:calcium ion homeostasis; IMP:RGD.
 GO:0071398; P:cellular response to fatty acid; IEP:RGD.
 GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
 GO:0070301; P:cellular response to hydrogen peroxide; IEP:RGD.
 GO:0009100; P:glycoprotein metabolic process; IEP:RGD.
 GO:0046483; P:heterocycle metabolic process; IEP:RGD.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0007259; P:JAK-STAT cascade; IMP:RGD.
 GO:0030324; P:lung development; IEP:RGD.
 GO:0001933; P:negative regulation of protein phosphorylation; IMP:RGD.
 GO:0031175; P:neuron projection development; IGI:UniProtKB.
 GO:0033687; P:osteoblast proliferation; IEP:RGD.
 GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IMP:RGD.
 GO:0010763; P:positive regulation of fibroblast migration; IMP:RGD.
 GO:0010628; P:positive regulation of gene expression; IMP:RGD.
 GO:0050729; P:positive regulation of inflammatory response; IMP:RGD.
 GO:1901018; P:positive regulation of potassium ion transmembrane transporter activity; IMP:RGD.
 GO:0001934; P:positive regulation of protein phosphorylation; IMP:RGD.
 GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:RGD.
 GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:RGD.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.
 GO:2000676; P:positive regulation of type B pancreatic cell apoptotic process; IMP:RGD.
 GO:0014823; P:response to activity; IEP:RGD.
 GO:0009750; P:response to fructose stimulus; IEP:RGD.
 GO:0055093; P:response to hyperoxia; IEP:RGD.
 GO:0060290; P:transdifferentiation; IEP:RGD. 
Interpro
 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 
Pfam
 PF08205; C2-set_2 
SMART
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE
 PS00290; IG_MHC 
PRINTS