UniProt Accession

 E7EVW7_HUMAN; E7EVW7 

Genbank Protein ID

 AC133750 

Genbank Nucleotide ID

  

Protein Name

 Hematopoietic lineage cell-specific protein 

Protein Synonyms/Alias

  

Gene Name

 HCLS1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
155	TSQKDYAKGFGGQYG	ubiquitination	[1]
204	GTRGLKAKFESMAEE	acetylation	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 449 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA. 

Interpro

 IPR003134; Hs1_Cortactin.
 IPR000108; p67phox.
 IPR001452; SH3_domain. 

Pfam

 PF02218; HS1_rep
 PF00018; SH3_1 

SMART

 SM00326; SH3 

PROSITE

 PS51090; CORTACTIN
 PS50002; SH3 

PRINTS

 PR00499; P67PHOX.
 PR00452; SH3DOMAIN.