UniProt Accession

 BOK_HUMAN; Q9UMX3 

Genbank Protein ID

 AF174487; BT007272; BC006203 

Genbank Nucleotide ID

 AAD51719.1; AAP35936.1 

Protein Name

 Bcl-2-related ovarian killer protein 

Protein Synonyms/Alias

 hBOK; Bcl-2-like protein 9; Bcl2-L-9 

Gene Name

 BOK 

Gene Synonyms/Alias

 BCL2L9 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
25	FDRSPTDKELVAQAK	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May play a role in apoptosis. 

Sequence Annotation

 MOTIF 32 44 BH4.
 MOTIF 66 82 BH3.
 MOTIF 112 131 BH1.
 MOTIF 164 178 BH2.  

Keyword

 Apoptosis; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 212 AA 

Protein Sequence

Gene Ontology

 GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0008283; P:cell proliferation; IEP:UniProtKB.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IMP:UniProtKB.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0048709; P:oligodendrocyte differentiation; IEA:Compara.
 GO:1900119; P:positive regulation of execution phase of apoptosis; IMP:UniProtKB. 

Interpro

 IPR002475; Bcl2-like.
 IPR026298; Blc2_fam.
 IPR026309; BOK. 

Pfam

 PF00452; Bcl-2 

SMART

  

PROSITE

 PS50062; BCL2_FAMILY
 PS01080; BH1
 PS01258; BH2
 PS01259; BH3
 PS01260; BH4_1
 PS50063; BH4_2 

PRINTS

 PR01862; BCL2FAMILY.