CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017049
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homeobox and leucine zipper protein Homez 
Protein Synonyms/Alias
 Homeodomain leucine zipper-containing factor 
Gene Name
 HOMEZ 
Gene Synonyms/Alias
 KIAA1443 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
230LQSSGLSKEQAGRGPubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May function as a transcriptional regulator. 
Sequence Annotation
 DNA_BIND 53 115 Homeobox 1.
 DNA_BIND 354 414 Homeobox 2.
 MOTIF 358 363 Nuclear localization signal (Potential).  
Keyword
 3D-structure; Complete proteome; DNA-binding; Homeobox; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 550 AA 
Protein Sequence
MVRGWEPPPG LDCAISEGHK SEGTMPPNKE ASGLSSSPAG LICLPPISEE LQLVWTQAAQ 60
TSELDSNEHL LKTFSYFPYP SLADIALLCL RYGLQMEKVK TWFMAQRLRC GISWSSEEIE 120
ETRARVVYRR DQLHFKSLLS FTHHAGRPPE EVPPPPVPAP EQVGIGIGPP TLSKPTQTKG 180
LKVEPEEPSQ MPPLPQSHQK LKESLMTPGS GAFPYQSDFW QHLQSSGLSK EQAGRGPNQS 240
HGIGTASWNH STTVPQPQAR DKPPPIALIA SSCKEESASS VTPSSSSTSS SFQVLANGAT 300
AASKPLQPLG CVPQSVSPSE QALPPHLEPA WPQGLRHNSV PGRVGPTEYL SPDMQRQRKT 360
KRKTKEQLAI LKSFFLQCQW ARREDYQKLE QITGLPRPEI IQWFGDTRYA LKHGQLKWFR 420
DNAVPGAPSF QDPAIPTPPP STRSLNERAE TPPLPIPPPP PDIQPLERYW AAHQQLRETD 480
IPQLSQASRL STQQVLDWFD SRLPQPAEVV VCLDEEEEEE EEELPEDDEE EEEEEEEDDD 540
DDDDDVIIQD 550 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR008422; Homeobox_KN_domain.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 
Pfam
 PF05920; Homeobox_KN 
SMART
 SM00389; HOX 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 
PRINTS