UniProt Accession

 AP5S1_HUMAN; Q9NUS5; B3KSD0; D3DVY7 

Genbank Protein ID

 AK002030; AK093332; AL109804; CH471133; CH471133; CH471133; CH471133; BC043344 

Genbank Nucleotide ID

 BAA92045.1; BAG52692.1; CAC17552.1; EAX10483.1; EAX10484.1; EAX10485.1; EAX10486.1; AAH43344.1 

Protein Name

 AP-5 complex subunit sigma-1 

Protein Synonyms/Alias

 Adapter-related protein complex 5 sigma subunit; Sigma5 

Gene Name

 AP5S1 

Gene Synonyms/Alias

 C20orf29 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	SCVFGAEKSPDDPRP	ubiquitination	[1]
51	ERDRLLRKEQILAVA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; DNA damage; DNA repair; Endosome; Lysosome; Membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 200 AA 

Protein Sequence

Gene Ontology

 GO:0030119; C:AP-type membrane coat adaptor complex; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005770; C:late endosome; IDA:UniProtKB.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB.
 GO:0016197; P:endosomal transport; IMP:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS