| Tag | Content |
|---|
| CPLM ID | CPLM-002715 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 5-hydroxytryptamine receptor 1A |
Protein Synonyms/Alias | 5-HT-1A; 5-HT1A; G-21; Serotonin receptor 1A |
Gene Name | HTR1A |
Gene Synonyms/Alias | ADRB2RL1; ADRBRL1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 334 | RNAEAKRKMALARER | ubiquitination | [1] |
|
Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
Sequence Annotation | CARBOHYD 10 10 N-linked (GlcNAc...) (Potential).
CARBOHYD 11 11 N-linked (GlcNAc...) (Potential).
CARBOHYD 24 24 N-linked (GlcNAc...) (Potential).
DISULFID 109 187 By similarity.
CROSSLNK 334 334 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Isopeptide bond; Membrane; Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 422 AA |
Protein Sequence | MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA VLGNACVVAA 60
IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC 120
TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED 180
RSDPDACTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT 240
RHGASPAPQP KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN 300
SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP 360
FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC 420
RQ 422 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0097458; C:neuron part; IEA:InterPro. GO:0004993; F:serotonin receptor activity; TAS:ProtInc. GO:0007610; P:behavior; TAS:ProtInc. GO:0008283; P:cell proliferation; IEA:InterPro. GO:0030815; P:negative regulation of cAMP metabolic process; IEA:InterPro. GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc. GO:0050795; P:regulation of behavior; IEA:InterPro. GO:0046883; P:regulation of hormone secretion; IEA:InterPro. GO:0042221; P:response to chemical stimulus; IEA:InterPro. GO:0042310; P:vasoconstriction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |