| Tag | Content |
|---|
| CPLM ID | CPLM-006073 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Antithrombin-III |
Protein Synonyms/Alias | ATIII; Serpin C1 |
Gene Name | Serpinc1 |
Gene Synonyms/Alias | At3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 209 | KLQPLDFKENPEQSR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). |
Sequence Annotation | BINDING 82 82 Heparin (By similarity).
BINDING 162 162 Heparin (By similarity).
BINDING 178 178 Heparin (By similarity).
CARBOHYD 129 129 N-linked (GlcNAc...).
CARBOHYD 168 168 N-linked (GlcNAc...).
CARBOHYD 188 188 N-linked (GlcNAc...).
CARBOHYD 225 225 N-linked (GlcNAc...) (Potential).
DISULFID 41 161 By similarity.
DISULFID 54 128 By similarity.
DISULFID 280 463 By similarity. |
Keyword | Blood coagulation; Complete proteome; Disulfide bond; Glycoprotein; Hemostasis; Heparin-binding; Phosphoprotein; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 465 AA |
Protein Sequence | MYSPGAGSGA AGERKLCLLS LLLIGALGCA ICHGNPVDDI CIAKPRDIPV NPLCIYRSPG 60
KKATEEDGSE QKVPEATNRR VWELSKANSR FATNFYQHLA DSKNDNDNIF LSPLSISTAF 120
AMTKLGACND TLKQLMEVFK FDTISEKTSD QIHFFFAKLN CRLYRKANKS SDLVSANRLF 180
GDKSLTFNES YQDVSEVVYG AKLQPLDFKE NPEQSRVTIN NWVANKTEGR IKDVIPQGAI 240
NELTALVLVN TIYFKGLWKS KFSPENTRKE PFYKVDGQSC PVPMMYQEGK FKYRRVAEGT 300
QVLELPFKGD DITMVLILPK PEKSLAKVEQ ELTPELLQEW LDELSETMLV VHMPRFRTED 360
GFSLKEQLQD MGLIDLFSPE KSQLPGIVAG GRDDLYVSDA FHKAFLEVNE EGSEAAASTS 420
VVITGRSLNP NRVTFKANRP FLVLIREVAL NTIIFMGRVA NPCVN 465 |
Gene Ontology | GO:0005576; C:extracellular region; IBA:RefGenome. GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell. GO:0008201; F:heparin binding; IEA:UniProtKB-KW. GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome. GO:0007596; P:blood coagulation; IEA:UniProtKB-KW. GO:0050728; P:negative regulation of inflammatory response; IEA:Compara. GO:0030162; P:regulation of proteolysis; IBA:RefGenome. GO:0007584; P:response to nutrient; IEA:Compara. |
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PROSITE | |
PRINTS | |