UniProt Accession

 CTDS1_MOUSE; P58466 

Genbank Protein ID

 AY028804; BC065158; BC079638 

Genbank Nucleotide ID

 AAK83555.1; AAH65158.1; AAH79638.1 

Protein Name

 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 

Protein Synonyms/Alias

 Golli-interacting protein; GIP; Nuclear LIM interactor-interacting factor 3; NLI-interacting factor 3; Small C-terminal domain phosphatase 1; SCP1; Small CTD phosphatase 1 

Gene Name

 Ctdsp1 

Gene Synonyms/Alias

 Nif3; Nliif 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
84	QYLLPEAKAQDSDKI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. 

Sequence Annotation

 DOMAIN 86 244 FCP1 homology.
 ACT_SITE 96 96 4-aspartylphosphate intermediate (By
 ACT_SITE 98 98 Proton donor (By similarity).
 METAL 96 96 Magnesium (By similarity).
 METAL 98 98 Magnesium; via carbonyl oxygen (By
 METAL 207 207 Magnesium (By similarity).  

Keyword

 Complete proteome; Hydrolase; Magnesium; Metal-binding; Nucleus; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008420; F:CTD phosphatase activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0050768; P:negative regulation of neurogenesis; IDA:MGI.
 GO:0045665; P:negative regulation of neuron differentiation; IDA:MGI.
 GO:0006470; P:protein dephosphorylation; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR011948; Dullard_phosphatase.
 IPR023214; HAD-like_dom.
 IPR004274; NIF. 

Pfam

 PF03031; NIF 

SMART

 SM00577; CPDc 

PROSITE

 PS50969; FCP1 

PRINTS