UniProt Accession

 APOA2_RAT; P04638 

Genbank Protein ID

 X03468; M28615 

Genbank Nucleotide ID

 CAA27185.1; AAA40750.1 

Protein Name

 Apolipoprotein A-II 

Protein Synonyms/Alias

 Apo-AII; ApoA-II; Apolipoprotein A2 

Gene Name

 Apoa2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
62	SEIQNQAKAYFQNAQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. 

Sequence Annotation

 MOD_RES 24 24 Pyrrolidone carboxylic acid (By  

Keyword

 Cleavage on pair of basic residues; Complete proteome; Disulfide bond; HDL; Lipid transport; Phosphoprotein; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 102 AA 

Protein Sequence

Gene Ontology

 GO:0042627; C:chylomicron; IEA:Compara.
 GO:0034366; C:spherical high-density lipoprotein particle; IEA:Compara.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:Compara.
 GO:0015485; F:cholesterol binding; IEA:Compara.
 GO:0017127; F:cholesterol transporter activity; IDA:RGD.
 GO:0008035; F:high-density lipoprotein particle binding; IEA:Compara.
 GO:0055102; F:lipase inhibitor activity; IEA:Compara.
 GO:0031210; F:phosphatidylcholine binding; IEA:Compara.
 GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Compara.
 GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
 GO:0002526; P:acute inflammatory response; IEP:RGD.
 GO:0033344; P:cholesterol efflux; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0046340; P:diacylglycerol catabolic process; IEA:Compara.
 GO:0034380; P:high-density lipoprotein particle assembly; IEA:Compara.
 GO:0034384; P:high-density lipoprotein particle clearance; IEA:Compara.
 GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Compara.
 GO:0042157; P:lipoprotein metabolic process; IEA:Compara.
 GO:0034374; P:low-density lipoprotein particle remodeling; IEA:Compara.
 GO:0060621; P:negative regulation of cholesterol import; IEA:Compara.
 GO:0060695; P:negative regulation of cholesterol transporter activity; IEA:Compara.
 GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IEA:Compara.
 GO:0060192; P:negative regulation of lipase activity; IEA:Compara.
 GO:0050995; P:negative regulation of lipid catabolic process; IEA:Compara.
 GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IEA:Compara.
 GO:0031100; P:organ regeneration; IDA:RGD.
 GO:0018206; P:peptidyl-methionine modification; IEA:Compara.
 GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:Compara.
 GO:0009395; P:phospholipid catabolic process; IEA:Compara.
 GO:0033700; P:phospholipid efflux; IEA:Compara.
 GO:0010873; P:positive regulation of cholesterol esterification; IEA:Compara.
 GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; ISS:UniProtKB.
 GO:0050996; P:positive regulation of lipid catabolic process; IEA:Compara.
 GO:0006457; P:protein folding; IEA:Compara.
 GO:0018158; P:protein oxidation; IEA:Compara.
 GO:0030300; P:regulation of intestinal cholesterol absorption; IEA:Compara.
 GO:0031647; P:regulation of protein stability; IEA:Compara.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0043627; P:response to estrogen stimulus; IEP:RGD.
 GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0043691; P:reverse cholesterol transport; IEA:Compara.
 GO:0034370; P:triglyceride-rich lipoprotein particle remodeling; IEA:Compara. 

Interpro

 IPR006801; ApoA-II. 

Pfam

 PF04711; ApoA-II 

SMART

  

PROSITE

  

PRINTS