UniProt Accession

 RL18A_HUMAN; Q02543 

Genbank Protein ID

 L05093; X80822; AC005796; BC007512; BC066319; BC071920 

Genbank Nucleotide ID

 AAC18781.1; CAA56788.1; AAC62828.1; AAH07512.1; AAH66319.1; AAH71920.1 

Protein Name

 60S ribosomal protein L18a 

Protein Synonyms/Alias

  

Gene Name

 RPL18A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
2	******MKASGTLRE	ubiquitination	[1, 2]
11	SGTLREYKVVGRCLP	ubiquitination	[1, 2, 3, 4, 5, 6, 7]
21	GRCLPTPKCHTPPLY	ubiquitination	[2, 5]
41	APNHVVAKSRFWYFV	ubiquitination	[1, 2, 3, 6, 7]
53	YFVSQLKKMKKSSGE	ubiquitination	[2]
56	SQLKKMKKSSGEIVY	ubiquitination	[2]
70	YCGQVFEKSPLRVKN	ubiquitination	[1, 2, 4]
76	EKSPLRVKNFGIWLR	ubiquitination	[2, 3, 5, 7]
128	AHSIQIMKVEEIAAS	ubiquitination	[1, 2, 6]
136	VEEIAASKCRRPAVK	ubiquitination	[1, 2, 4, 5]
143	KCRRPAVKQFHDSKI	ubiquitination	[1, 3, 5, 6, 7]
149	VKQFHDSKIKFPLPH	ubiquitination	[2]
151	QFHDSKIKFPLPHRV	ubiquitination	[2, 3, 5, 7]
170	HKPRFTTKRPNTFF*	ubiquitination	[2, 3, 5, 6, 7]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [7] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 MOD_RES 63 63 Phosphotyrosine.
 MOD_RES 71 71 Phosphoserine.
 MOD_RES 123 123 Phosphoserine (By similarity).  

Keyword

 3D-structure; Complete proteome; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 176 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006414; P:translational elongation; TAS:Reactome.
 GO:0006413; P:translational initiation; TAS:Reactome.
 GO:0006415; P:translational termination; TAS:Reactome.
 GO:0019083; P:viral transcription; TAS:Reactome. 

Interpro

 IPR021138; Ribosomal_L18a.
 IPR023573; Ribosomal_L18a/LX. 

Pfam

 PF01775; Ribosomal_L18ae 

SMART

  

PROSITE

  

PRINTS