| Tag | Content |
|---|
| CPLM ID | CPLM-005013 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dihydrolipoyl dehydrogenase |
Protein Synonyms/Alias | Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; S complex, 50 kDa subunit |
Gene Name | pdhD |
Gene Synonyms/Alias | aceD; citL; BSU14610 |
Created Date | July 27, 2013 |
Organism | Bacillus subtilis (strain 168) |
NCBI Taxa ID | 224308 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 108 | GGVAGLLKGNKVDVV | acetylation | [1] | | 173 | STGALALKEIPKKLV | acetylation | [1] | | 298 | MTDRGIVKTDKQCRT | acetylation | [1] |
|
Reference | [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis. Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG. Proteomics. 2013 May;13(10-11):1726-36. [ PMID: 23468065] |
Functional Description | Catalyzes the oxidation of dihydrolipoamide to lipoamide. |
Sequence Annotation | NP_BIND 39 47 FAD (By similarity).
NP_BIND 183 187 NAD (By similarity).
NP_BIND 272 275 NAD (By similarity).
ACT_SITE 447 447 Proton acceptor (By similarity).
BINDING 56 56 FAD (By similarity).
BINDING 119 119 FAD; via amide nitrogen and carbonyl
BINDING 206 206 NAD (By similarity).
BINDING 315 315 FAD (By similarity).
BINDING 323 323 FAD; via amide nitrogen (By similarity).
DISULFID 47 52 Redox-active (By similarity). |
Keyword | Complete proteome; Cytoplasm; Disulfide bond; FAD; Flavoprotein; Glycolysis; NAD; Oxidoreductase; Redox-active center; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 470 AA |
Protein Sequence | MVVGDFPIET DTLVIGAGPG GYVAAIRAAQ LGQKVTVVEK ATLGGVCLNV GCIPSKALIN 60
AGHRYENAKH SDDMGITAEN VTVDFTKVQE WKASVVNKLT GGVAGLLKGN KVDVVKGEAY 120
FVDSNSVRVM DENSAQTYTF KNAIIATGSR PIELPNFKYS ERVLNSTGAL ALKEIPKKLV 180
VIGGGYIGTE LGTAYANFGT ELVILEGGDE ILPGFEKQMS SLVTRRLKKK GNVEIHTNAM 240
AKGVEERPDG VTVTFEVKGE EKTVDADYVL ITVGRRPNTD ELGLEQVGIE MTDRGIVKTD 300
KQCRTNVPNI YAIGDIIEGP PLAHKASYEG KIAAEAIAGE PAEIDYLGIP AVVFSEPELA 360
SVGYTEAQAK EEGLDIVAAK FPFAANGRAL SLNETDGFMK LITRKEDGLV IGAQIAGASA 420
SDMISELSLA IEGGMTAEDI AMTIHAHPTL GEITMEAAEV AIGSPIHIVK 470 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0004148; F:dihydrolipoyl dehydrogenase activity; IEA:EC. GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. GO:0045454; P:cell redox homeostasis; IEA:InterPro. GO:0006096; P:glycolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |