Tag | Content |
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CPLM ID | CPLM-005474 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nucleolar transcription factor 1 |
Protein Synonyms/Alias | Upstream-binding factor 1; UBF-1 |
Gene Name | Ubtf |
Gene Synonyms/Alias | Tcfubf; Ubf-1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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612 | QRISQSQKEHYKKLA | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element (By similarity). |
Sequence Annotation | DNA_BIND 112 180 HMG box 1. DNA_BIND 196 264 HMG box 2. DNA_BIND 298 362 HMG box 3. DNA_BIND 407 475 HMG box 4. DNA_BIND 482 549 HMG box 5. DNA_BIND 568 634 HMG box 6. MOD_RES 1 1 N-acetylmethionine (By similarity). MOD_RES 201 201 Phosphothreonine (By similarity). MOD_RES 273 273 Phosphoserine (By similarity). MOD_RES 336 336 Phosphoserine (By similarity). MOD_RES 364 364 Phosphoserine (By similarity). MOD_RES 389 389 Phosphoserine (By similarity). MOD_RES 412 412 Phosphoserine (By similarity). MOD_RES 433 433 Phosphoserine (By similarity). MOD_RES 484 484 Phosphoserine (By similarity). MOD_RES 495 495 Phosphoserine (By similarity). MOD_RES 546 546 Phosphoserine (By similarity). MOD_RES 584 584 Phosphoserine (By similarity). MOD_RES 638 638 Phosphoserine (By similarity). |
Keyword | Acetylation; Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 764 AA |
Protein Sequence | MNGEADCPTD LEMAAPKGQD RWSQEDMLTL LECMKNNLPS NDSSKFKTTE SHMDWEKVAF 60 KDFSGDMCKL KWVEISNEVR KFRTLTELIL DAQEHVKNPY KGKKLKKHPD FPKKPLTPYF 120 RFFMEKRAKY AKLHPEMSNL DLTKILSKKY KELPEKKKMK YIQDFQREKQ EFERNLARFR 180 EDHPDLIQNA KKSDIPEKPK TPQQLWYTHE KKVYLKVRPD ATTKEVKDSL GKQWSQLSDK 240 KRLKWIHKAL EQRKEYEEIM RDYIQKHPEL NISEEGITKS TLTKAERQLK DKFDGRPTKP 300 PPNSYSLYCA ELMANMKDVP STERMVLCSQ QWKLLSQKEK DAYHKKCDQK KKDYEVELLR 360 FLESLPEEEQ QRVLGEEKML NINKKQTTSP ASKKPSQEGG KGGSEKPKRP VSAMFIFSEE 420 KRRQLQEERP ELSESELTRL LARMWNDLSE KKKAKYKARE AALKAQSERK PGGEREDRGK 480 LPESPKRAEE IWQQSVIGDY LARFKNDRVK ALKAMEMTWN NMEKKEKLMW IKKAAEDQKR 540 YERELSEMRA PPAATNSSKK MKFQGEPKKP PMNGYQKFSQ ELLSNGELNH LPLKERMVEI 600 GSRWQRISQS QKEHYKKLAE EQQRQYKVHL DLWVKSLSPQ DRAAYKEYIS NKRKNMTKLR 660 GPNPKSSRTT LQSKSESEED DDEEDDDDDD EEEEEDDENG DSSEDGGDSS ESSSEDESED 720 GDENEDDDDD EDDDEDDDED EDNESEGSSS SSSSSGDSSD SDSN 764 |
Gene Ontology | GO:0005730; C:nucleolus; ISS:UniProtKB. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0000183; P:chromatin silencing at rDNA; IEA:Compara. GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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PRINTS | |