UniProt Accession

 HHA_ECOLI; P0ACE3; P23870; P77120; Q2MBW7 

Genbank Protein ID

 X57977; U82664; U00096; AP009048 

Genbank Nucleotide ID

 CAA41043.1; AAB40215.1; AAC73562.1; BAE76239.1 

Protein Name

 Hemolysin expression-modulating protein Hha 

Protein Synonyms/Alias

  

Gene Name

 hha 

Gene Synonyms/Alias

 b0460; JW0449 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
32	ERVIEKNKYELSDNE	acetylation	[1]
58	LAELTMNKLYDKIPS	acetylation	[1]
62	TMNKLYDKIPSSVWK	acetylation	[1]
69	KIPSSVWKFIR****	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Down-regulates hemolysin production and can also stimulate transposition events in vivo. Binds DNA and influences DNA topology in response to environmental stimuli. Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR. Decreases biofilm formation by repressing the transcription of fimbrial genes fimA and ihfA, and by repressing the transcription of tRNAs corresponding to rare codons, which are abundant in type 1 fimbrial genes. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; DNA-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 72 AA 

Protein Sequence

Gene Ontology

 GO:0003677; F:DNA binding; IDA:EcoCyc.
 GO:0010468; P:regulation of gene expression; IMP:EcoCyc. 

Interpro

 IPR007985; Hemolysn_expr_modulating_HHA. 

Pfam

 PF05321; HHA 

SMART

  

PROSITE

  

PRINTS