CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005782
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calreticulin 
Protein Synonyms/Alias
  
Gene Name
 Crc 
Gene Synonyms/Alias
 CG9429 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
159GKNHLISKDIRCKDDacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). 
Sequence Annotation
 REPEAT 191 202 1-1.
 REPEAT 210 221 1-2.
 REPEAT 227 238 1-3.
 REPEAT 244 255 1-4.
 REPEAT 259 269 2-1.
 REPEAT 273 283 2-2.
 REPEAT 287 297 2-3.
 REGION 191 255 4 X approximate repeats.
 REGION 259 297 3 X approximate repeats.
 BINDING 109 109 Carbohydrate (By similarity).
 BINDING 111 111 Carbohydrate (By similarity).
 BINDING 128 128 Carbohydrate (By similarity).
 BINDING 135 135 Carbohydrate (By similarity).
 BINDING 317 317 Carbohydrate (By similarity).
 DISULFID 105 137 By similarity.  
Keyword
 Calcium; Chaperone; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Lectin; Metal-binding; Reference proteome; Repeat; Signal; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 406 AA 
Protein Sequence
MMWCKTVIVL LATVGFISAE VYLKENFDNE NWEDTWIYSK HPGKEFGKFV LTPGTFYNDA 60
EADKGIQTSQ DARFYAASRK FDGFSNEDKP LVVQFSVKHE QNIDCGGGYV KLFDCSLDQT 120
DMHGESPYEI MFGPDICGPG TKKVHVIFSY KGKNHLISKD IRCKDDVYTH FYTLIVRPDN 180
TYEVLIDNEK VESGNLEDDW DFLAPKKIKD PTATKPEDWD DRATIPDPDD KKPEDWDKPE 240
HIPDPDATKP EDWDDEMDGE WEPPMIDNPE FKGEWQPKQL DNPNYKGAWE HPEIANPEYV 300
PDDKLYLRKE ICTLGFDLWQ VKSGTIFDNV LITDDVELAA KAAAEVKNTQ AGEKKMKEAQ 360
DEVQRKKDEE EAKKASDKDD EDEDDDDEEK DDESKQDKDQ SEHDEL 406 
Gene Ontology
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; IDA:FlyBase.
 GO:0045169; C:fusome; IDA:FlyBase.
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0048854; P:brain morphogenesis; IMP:FlyBase.
 GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
 GO:0031987; P:locomotion involved in locomotory behavior; IMP:FlyBase.
 GO:0022008; P:neurogenesis; IMP:FlyBase.
 GO:0042048; P:olfactory behavior; IMP:FlyBase.
 GO:0007422; P:peripheral nervous system development; TAS:FlyBase.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0030431; P:sleep; IMP:FlyBase.
 GO:0001964; P:startle response; IMP:FlyBase. 
Interpro
 IPR001580; Calret/calnex.
 IPR018124; Calret/calnex_CS.
 IPR009169; Calreticulin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp. 
Pfam
 PF00262; Calreticulin 
SMART
  
PROSITE
 PS00803; CALRETICULIN_1
 PS00804; CALRETICULIN_2
 PS00805; CALRETICULIN_REPEAT
 PS00014; ER_TARGET 
PRINTS
 PR00626; CALRETICULIN.