CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002297
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Beta-crystallin A3 
Protein Synonyms/Alias
 Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form 
Gene Name
 CRYBA1 
Gene Synonyms/Alias
 CRYB1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
44DQENFQGKRMEFTSSmethylation[1]
122PICSANHKESKMTIFacetylation[2]
125SANHKESKMTIFEKEacetylation[2]
131SKMTIFEKENFIGRQacetylation[2]
Reference
 [1] Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility?
 Wilmarth PA, Tanner S, Dasari S, Nagalla SR, Riviere MA, Bafna V, Pevzner PA, David LL.
 J Proteome Res. 2006 Oct;5(10):2554-66. [PMID: 17022627]
 [2] Shotgun identification of protein modifications from protein complexes and lens tissue.
 MacCoss MJ, McDonald WH, Saraf A, Sadygov R, Clark JM, Tasto JJ, Gould KL, Wolters D, Washburn M, Weiss A, Clark JI, Yates JR 3rd.
 Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7900-5. [PMID: 12060738
Functional Description
 Crystallins are the dominant structural components of the vertebrate eye lens. 
Sequence Annotation
 DOMAIN 31 70 Beta/gamma crystallin 'Greek key' 1.
 DOMAIN 71 117 Beta/gamma crystallin 'Greek key' 2.
 DOMAIN 124 165 Beta/gamma crystallin 'Greek key' 3.
 DOMAIN 166 214 Beta/gamma crystallin 'Greek key' 4.
 REGION 1 30 N-terminal arm.
 REGION 118 123 Connecting peptide.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 82 82 S-glutathionyl cysteine; alternate.
 MOD_RES 82 82 S-methylcysteine; alternate.
 MOD_RES 117 117 S-glutathionyl cysteine; alternate.
 MOD_RES 117 117 S-methylcysteine; alternate.  
Keyword
 Acetylation; Alternative initiation; Cataract; Complete proteome; Direct protein sequencing; Eye lens protein; Glutathionylation; Methylation; Oxidation; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 215 AA 
Protein Sequence
METQAEQQEL ETLPTTKMAQ TNPTPGSLGP WKITIYDQEN FQGKRMEFTS SCPNVSERSF 60
DNVRSLKVES GAWIGYEHTS FCGQQFILER GEYPRWDAWS GSNAYHIERL MSFRPICSAN 120
HKESKMTIFE KENFIGRQWE ISDDYPSLQA MGWFNNEVGS MKIQSGAWVC YQYPGYRGYQ 180
YILECDHHGG DYKHWREWGS HAQTSQIQSI RRIQQ 215 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0007601; P:visual perception; IMP:UniProtKB. 
Interpro
 IPR001064; Beta/gamma_crystallin.
 IPR011024; G_crystallin-rel. 
Pfam
 PF00030; Crystall 
SMART
 SM00247; XTALbg 
PROSITE
 PS50915; CRYSTALLIN_BETA_GAMMA 
PRINTS
 PR01367; BGCRYSTALLIN.