UniProt Accession

 GSTO1_RAT; Q9Z339 

Genbank Protein ID

 AB008807 

Genbank Nucleotide ID

 BAA34217.1 

Protein Name

 Glutathione S-transferase omega-1 

Protein Synonyms/Alias

 GSTO-1; Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; S-(Phenacyl)glutathione reductase; SPG-R 

Gene Name

 Gsto1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
152	ELKKEFSKLEEAMAN	acetylation	[1]
160	LEEAMANKRTAFFGG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid (By similarity). 

Sequence Annotation

 DOMAIN 22 101 GST N-terminal.
 DOMAIN 106 228 GST C-terminal.
 REGION 85 86 Glutathione binding (By similarity).
 ACT_SITE 32 32 Nucleophile (By similarity).
 BINDING 59 59 Glutathione (By similarity).
 BINDING 72 72 Glutathione; via amide nitrogen and
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 57 57 N6-acetyllysine (By similarity).
 MOD_RES 143 143 N6-acetyllysine (By similarity).
 MOD_RES 148 148 N6-acetyllysine (By similarity).
 MOD_RES 152 152 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Oxidoreductase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 241 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:RGD.
 GO:0005604; C:basement membrane; IDA:RGD.
 GO:0044297; C:cell body; IDA:RGD.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0043209; C:myelin sheath; IDA:RGD.
 GO:0031965; C:nuclear membrane; IDA:RGD.
 GO:0045174; F:glutathione dehydrogenase (ascorbate) activity; IDA:RGD.
 GO:0004364; F:glutathione transferase activity; ISS:UniProtKB.
 GO:0050610; F:methylarsonate reductase activity; IEA:EC.
 GO:0071243; P:cellular response to arsenic-containing substance; ISS:UniProtKB.
 GO:0019853; P:L-ascorbic acid biosynthetic process; IMP:RGD.
 GO:0042178; P:xenobiotic catabolic process; ISS:UniProtKB. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR005442; GST_omega.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01625; GSTRNSFRASEO.