CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-029212
UniProt Accession
A7E2X7_HUMAN
;
A7E2X7
Genbank Protein ID
BC151237
Genbank Nucleotide ID
AAI51238.1
Protein Name
Topoisomerase (DNA) II binding protein 1
Protein Synonyms/Alias
Gene Name
TOPBP1
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Lysine Modification
Position
Peptide
Type
References
137
EVQQLTV
K
HGGQYMG
ubiquitination
[1]
1334
LLQSGGA
K
VLPGHSV
ubiquitination
[1]
Reference
[1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [
PMID: 23603789
]
Functional Description
Sequence Annotation
Keyword
Isomerase.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
1435 AA
Protein Sequence
MHHQRCVPRA EHPVYNMVMS DVTISCTSLE KEKREEVHKY VQMMGGRVYR DLNVSVTHLI 60
AGEVGSKKYL VAANLKKPIL LPSWIKTLWE KSQEKKITRY TDINMEDFKC PIFLGCIICV 120
TGLCGLDRKE VQQLTVKHGG QYMGQLKMNE CTHLIVQEPK GQKYECAKRW NVHCVTTQWF 180
FDSIEKGFCQ DESIYKTEPR PEAKTMPNSS TPTSQINTID SRTLSDVSNI SNINASCVSE 240
SICNSLNSKL EPTLENLENL DVSAFQAPED LLDGCRIYLC GFSGRKLDKL RRLINSGGGV 300
RFNQLNEDVT HVIVGDYDDE LKQFWNKSAH RPHVVGAKWL LECFSKGYML SEEPYIHANY 360
QPVEIPVSHQ PESKAALLKK KNSSFSKKDF APSEKHEQAD EDLLSQYENG SSTVVEAKTS 420
EARPFNDSTH AEPLNDSTHI SLQEENQSSV SHCVPDVSTI TEEGLFSQKS FLVLGFSNEN 480
ESNIANIIKE NAGKIMSLLS RTVADYAVVP LLGCEVEATV GEVVTNTWLV TCIDYQTLFD 540
PKSNPLFTPV PVMTGMTPLE DCVISFSQCA GAEKESLTFL ANLLGASVQE YFVRKSNAKK 600
GMFASTHLIL KERGGSKYEA AKKWNLPAVT IAWLLETART GKRADESHFL IENSTKEERS 660
LETEITNGIN LNSDTAEHPG TRLQTHRKTV VTPLDMNRFQ SKAFRAVVSQ HARQVAASPA 720
VGQPLQKEPS LHLDTPSKFL SKDKLFKPSF DVKDALAALE TPGRPSQQKR KPSTPLSEVI 780
VKNLQLALAN SSRNAVALSA SPQLKEAQSE KEEAPKPLHK VVVCVSKKLS KKQSELNGIA 840
ASLGADYRWS FDETVTHFIY QGRPNDTNRE YKSVKERGVH IVSEHWLLDC AQECKHLPES 900
LYPHTYNPKM SLDISAVQDG RLCNSRLLSA VSSTKDDEPD PLILEENDVD NMATNNKESA 960
PSNGSGKNDS KGVLTQTLEM RENFQKQLQE IMSATSIVKP QGQRTSLSRS GCNSASSTPD 1020
STRSARSGRS RVLEALRQSR QTVPDVNTEP SQNEQIIWDD PTAREERARL ASNLQWPSCP 1080
TQYSELQVDI QNLEDSPFQK PLHDSEIAKQ AVCDPGNIRV TEAPKHPISE ELETPIKDSH 1140
LIPTPQAPSI AFPLANPPVA PHPREKIITI EETHEELKKQ YIFQLSSLNP QERIDYCHLI 1200
EKLGGLVIEK QCFDPTCTHI VVGHPLRNEK YLASVAAGKW VLHRSYLEAC RTAGHFVQEE 1260
DYEWGSSSIL DVLTGINVQQ RRLALAAMRW RKKIQQRQES GIVEGAFSGW KVILHVDQSR 1320
EAGFKRLLQS GGAKVLPGHS VPLFKEATHL FSDLNKLKPD DSGVNIAEAA AQNVYCLRTE 1380
YIADYLMQES PPHVENYCLP EAISFIQNNK ELGTGLSQKR KAPTEKNKIK RPRVH 1435
Gene Ontology
GO:0016853
; F:isomerase activity; IEA:UniProtKB-KW.
Interpro
IPR001357
; BRCT_dom.
IPR016126
; Secretoglobin.
IPR026993
; Topbp1.
Pfam
PF00533
; BRCT
PF12738
; PTCB-BRCT
SMART
SM00292
; BRCT
PROSITE
PS50172
; BRCT
PRINTS