| Tag | Content |
|---|
| CPLM ID | CPLM-000560 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 26S proteasome non-ATPase regulatory subunit 4 |
Protein Synonyms/Alias | 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; Multiubiquitin chain-binding protein |
Gene Name | Psmd4 |
Gene Synonyms/Alias | Mcb1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 40 | VNIVCHSKTRSNPEN | ubiquitination | [1] | | 74 | DTGRILSKLHTVQPK | ubiquitination | [1] | | 122 | SPVEDNEKDLVKLAK | ubiquitination | [1] | | 126 | DNEKDLVKLAKRLKK | ubiquitination | [1] | | 135 | AKRLKKEKVNVDIIN | ubiquitination | [1] | | 367 | ALASQATKDGKNDKK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds and presumably selects ubiquitin-conjugates for destruction. |
Sequence Annotation | DOMAIN 5 188 VWFA.
REPEAT 211 230 UIM 1.
REPEAT 282 301 UIM 2.
MOD_RES 250 250 Phosphothreonine.
MOD_RES 253 253 Phosphothreonine.
MOD_RES 256 256 Phosphoserine.
MOD_RES 360 360 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Phosphoprotein; Proteasome; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 376 AA |
Protein Sequence | MVLESTMVCV DNSEYMRNGD FLPTRLQAQQ DAVNIVCHSK TRSNPENNVG LITLANDCEV 60
LTTLTPDTGR ILSKLHTVQP KGKITFCTGI RVAHLALKHR QGKNHKMRII AFVGSPVEDN 120
EKDLVKLAKR LKKEKVNVDI INFGEEEVNT EKLTAFVNTL NGKDGTGSHL VTVPPGPSLA 180
DALISSPILA GEGGAMLGLG ASDFEFGVDP SADPELALAL RVSMEEQRQR QEEEARRAAA 240
ASAAEAGIAT PGTEGERDSD DALLKMTINQ QEFGRPGLPD LSSMTEEEQI AYAMQMSLQG 300
TEFSQESADM DASSAMDTSD PVKEEDDYDV MQDPEFLQSV LENLPGVDPN NAAIRSVMGA 360
LASQATKDGK NDKKEEEKK 379 |
Gene Ontology | GO:0022624; C:proteasome accessory complex; IDA:UniProtKB. GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:InterPro. GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |