CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029160
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 S-adenosylmethionine decarboxylase proenzyme 
Protein Synonyms/Alias
 cDNA FLJ52754, highly similar to S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50) 
Gene Name
 AMD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
67KALVPLLKLARDYSGubiquitination[1]
172MKDGVTAKDVTRESGubiquitination[2, 3, 4]
262LFVNQSSKCRTVLASubiquitination[3, 4]
272TVLASPQKIEGFKRLubiquitination[1, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 ACT_SITE 39 39 Schiff-base intermediate with substrate;
 ACT_SITE 53 53 Proton donor; for catalytic activity (By
 ACT_SITE 200 200 Proton acceptor; for processing activity
 ACT_SITE 214 214 Proton acceptor; for processing activity
 MOD_RES 39 39 Pyruvic acid (Ser); by autocatalysis (By  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 305 AA 
Protein Sequence
MEAAHFFEGT EKLLEVWFSR QQPDANQGSG DLRTIPSESS MFVSKRRFIL KTCGTTLLLK 60
ALVPLLKLAR DYSGFDSIQS FFYSRKNFMK PSHQGYPHRN FQEEIEFLNA IFPNGAAYCM 120
GRMNSDCWYL YTLDFPESRV ISQPDQTLEI LMSELDPAVM DQFYMKDGVT AKDVTRESGI 180
RDLIPGSVID ATMFNPCGYS MNGMKSDGTY WTIHITPEPE FSYVSFETNL SQTSYDDLIR 240
KVVEVFKPGK FVTTLFVNQS SKCRTVLASP QKIEGFKRLD CQSAMFNDYN FVFTSFAKKQ 300
QQQQS 305 
Gene Ontology
 GO:0004014; F:adenosylmethionine decarboxylase activity; IEA:InterPro.
 GO:0008295; P:spermidine biosynthetic process; IEA:InterPro.
 GO:0006597; P:spermine biosynthetic process; IEA:InterPro. 
Interpro
 IPR001985; S-AdoMet_decarboxylase.
 IPR018167; S-AdoMet_decarboxylase_subgr.
 IPR016067; S-AdoMet_deCO2ase_core. 
Pfam
 PF01536; SAM_decarbox 
SMART
  
PROSITE
  
PRINTS