UniProt Accession

 S27A4_HUMAN; Q6P1M0; A8K2F7; O95186 

Genbank Protein ID

 AF055899; AK290222; AL359091; CH471090; BC065003 

Genbank Nucleotide ID

 AAD11623.1; BAF82911.1; CAI13490.1; EAW87779.1; AAH65003.1 

Protein Name

 Long-chain fatty acid transport protein 4 

Protein Synonyms/Alias

 FATP-4; Fatty acid transport protein 4; Solute carrier family 27 member 4 

Gene Name

 SLC27A4 

Gene Synonyms/Alias

 ACSVL4; FATP4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
90	TVRRHPDKTALIFEG	ubiquitination	[1]
454	LVGRIIQKDPLRRFD	ubiquitination	[1]
471	LNQGANNKKIAKDVF	ubiquitination	[1]
475	ANNKKIAKDVFKKGD	ubiquitination	[1]
512	TGDTFRWKGENVSTT	ubiquitination	[1]
571	RFAQVLEKELPLYAR	ubiquitination	[1, 2]
612	GFDPAIVKDPLFYLD	ubiquitination	[1]
622	LFYLDAQKGRYVPLD	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity). 

Sequence Annotation

 NP_BIND 243 254 AMP (Potential).  

Keyword

 Complete proteome; Disease mutation; Fatty acid metabolism; Ichthyosis; Ligase; Lipid metabolism; Lipid transport; Membrane; Nucleotide-binding; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 643 AA 

Protein Sequence

Gene Ontology

 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005902; C:microvillus; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0015245; F:fatty acid transporter activity; TAS:ProtInc.
 GO:0004467; F:long-chain fatty acid-CoA ligase activity; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0031957; F:very long-chain fatty acid-CoA ligase activity; IEA:Compara.
 GO:0044539; P:long-chain fatty acid import; IDA:UniProtKB.
 GO:0001579; P:medium-chain fatty acid transport; IEA:Compara.
 GO:0043588; P:skin development; IEA:Compara.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0042760; P:very long-chain fatty acid catabolic process; IEA:Compara. 

Interpro

 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig.
 IPR022272; Lipocalin_CS. 

Pfam

 PF00501; AMP-binding 

SMART

  

PROSITE

 PS00455; AMP_BINDING 

PRINTS