CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001919
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HLA class I histocompatibility antigen, B-7 alpha chain 
Protein Synonyms/Alias
 MHC class I antigen B*7 
Gene Name
 HLA-B 
Gene Synonyms/Alias
 HLAB 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
92DRNTQIYKAQAQTDRubiquitination[1]
145DQYAYDGKDYIALNEubiquitination[1, 2]
170AAQITQRKWEAAREAubiquitination[1, 2]
200RRYLENGKDKLERADubiquitination[1]
202YLENGKDKLERADPPubiquitination[2]
267AGDRTFQKWAAVVVPubiquitination[1, 2, 3]
292VQHEGLPKPLTLRWEubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Involved in the presentation of foreign antigens to the immune system. 
Sequence Annotation
 DOMAIN 209 295 Ig-like C1-type.
 REGION 25 114 Alpha-1.
 REGION 115 206 Alpha-2.
 REGION 207 298 Alpha-3.
 REGION 299 309 Connecting peptide.
 CARBOHYD 110 110 N-linked (GlcNAc...).
 DISULFID 125 188
 DISULFID 227 283  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Host-virus interaction; Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 362 AA 
Protein Sequence
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF 60
DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ 120
SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR 180
RAYLEGECVE WLRRYLENGK DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 240
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 300
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL 360
TA 362 
Gene Ontology
 GO:0031901; C:early endosome membrane; TAS:Reactome.
 GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:2001198; P:regulation of dendritic cell differentiation; IMP:BHF-UCL.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:0032655; P:regulation of interleukin-12 production; IMP:BHF-UCL.
 GO:0032675; P:regulation of interleukin-6 production; IMP:BHF-UCL.
 GO:0002667; P:regulation of T cell anergy; IMP:BHF-UCL.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2.
 IPR010579; MHC_I_a_C. 
Pfam
 PF07654; C1-set
 PF00129; MHC_I
 PF06623; MHC_I_C 
SMART
 SM00407; IGc1 
PROSITE
 PS50835; IG_LIKE
 PS00290; IG_MHC 
PRINTS
 PR01638; MHCCLASSI.