UniProt Accession

 UBXN1_MOUSE; Q922Y1; Q3UCP8 

Genbank Protein ID

 AK150442; BC006701 

Genbank Nucleotide ID

 BAE29564.1; AAH06701.1 

Protein Name

 UBX domain-containing protein 1 

Protein Synonyms/Alias

 Protein 2B28; SAPK substrate protein 1; UBA/UBX 33.3 kDa protein; mY33K 

Gene Name

 Ubxn1 

Gene Synonyms/Alias

 D19Ertd721e; Saks1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
96	EERQEQTKRMLELVA	ubiquitination	[1]
105	MLELVAQKQREREER	ubiquitination	[1]
137	ELSVARQKLQEDEMR	ubiquitination	[1]
154	AEERRREKAEELAAR	ubiquitination	[1]
208	PSQEPPTKREYDQCR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (By similarity) Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems. 

Sequence Annotation

 DOMAIN 1 42 UBA.
 DOMAIN 209 291 UBX.
 REGION 43 297 Interaction with BRCA1 (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 187 187 Phosphoserine.
 MOD_RES 192 192 Phosphothreonine.
 MOD_RES 199 199 Phosphoserine (By similarity).
 MOD_RES 200 200 Phosphoserine; by MAPK12 (By similarity).
 MOD_RES 270 270 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0034098; C:Cdc48p-Npl4p-Ufd1p AAA ATPase complex; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0000502; C:proteasome complex; IEA:Compara.
 GO:0071796; F:K6-linked polyubiquitin binding; ISS:UniProtKB.
 GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
 GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB. 

Interpro

 IPR009060; UBA-like.
 IPR000449; UBA/transl_elong_EF1B_N.
 IPR015940; UBA/transl_elong_EF1B_N_euk.
 IPR001012; UBX. 

Pfam

 PF00627; UBA
 PF00789; UBX 

SMART

 SM00165; UBA
 SM00166; UBX 

PROSITE

 PS50030; UBA
 PS50033; UBX 

PRINTS