CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044369
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Homeodomain-interacting protein kinase 1 
Protein Synonyms/Alias
  
Gene Name
 HIPK1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
120SLLEPYQKCGLKRKSubiquitination[1]
213KCWKRSTKEIVAIKIubiquitination[1]
440GYPLWRLKTPEEHELubiquitination[1, 2]
452HELETGIKSKEARKYubiquitination[2]
496REYIDLLKKMLTIDAubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1176 AA 
Protein Sequence
MASQLQVFSP PSVSSSAFCS AKKLKIEPSG WDVSGQSSND KYYTHSKTLP ATQGQANSSH 60
QVANFNIPAY DQGLLLPAPA VEHIVVTAAD SSGSAATSTF QSSQTLTHRS NVSLLEPYQK 120
CGLKRKSEEV DSNGSVQIIE EHPPLMLQNR TVVGAAATTT TVTTKSSSSS GEGDYQLVQH 180
EILCSMTNSY EVLEFLGRGT FGQVAKCWKR STKEIVAIKI LKNHPSYARQ GQIEVSILSR 240
LSSENADEYN FVRSYECFQH KNHTCLVFEM LEQNLYDFLK QNKFSPLPLK YIRPILQQVA 300
TALMKLKSLG LIHADLKPEN IMLVDPVRQP YRVKVIDFGS ASHVSKAVCS TYLQSRYYRA 360
PEIILGLPFC EAIDMWSLGC VIAELFLGWP LYPGASEYDQ IRYISQTQGL PAEYLLSAGT 420
KTTRFFNRDP NLGYPLWRLK TPEEHELETG IKSKEARKYI FNCLDDMAQV NMSTDLEGTD 480
MLAEKADRRE YIDLLKKMLT IDADKRITPL KTLNHQFVTM THLLDFPHSN HVKSCFQNME 540
ICKRRVHMYD TASVLASSST AAAATLSLAN SDVSLLNYQS ALYPSSAAPV PGVAQQGVSL 600
QPGTTQICTQ TDPFQQTFIV CPPAFQTGLQ ATTKHSGFPV RMDNAVPIVP QAPAAQPLQI 660
QSGVLTQGSC TPLMVATLHP QVATITPQYA VPFTLSCAAG RPALVEQTAA VLQAWPGGTQ 720
QILLPSTWQQ LPGVALHNSV QPTAMIPEAM GSGQQLADWR NAHSHGNQYS TIMQQPSLLT 780
NHVTLATAQP LNVGVAHVVR QQQSSSLPSK KNKQSAPVSS KSSLDVLPSQ VYSLVGSSPL 840
RTTSSYNSLV PVQDQHQPII IPDTPSPPVS VITIRSDTDE EEDNKYKPSS SGLKPRSNVI 900
SYVTVNDSPD SDSSLSSPYS TDTLSALRGN SGSVLEGPGR VVADGTGTRT IIVPPLKTQL 960
GDCTVATQAS GLLSNKTKPV ASVSGQSSGC CITPTGYRAQ RGGTSAAQPL NLSQNQQSSA 1020
APTSQERSSN PAPRRQQAFV APLSQAPYTF QHGSPLHSTG HPHLAPAPAH LPSQAHLYTY 1080
AAPTSAAALG STSSIAHLFS PQGSSRHAAA YTTHPSTLVH QVPVSVGPSL LTSASVAPAQ 1140
YQHQFATQSY IGSSRGSTIY TGYPLSPTKI SQYSYL 1176 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS