UniProt Accession

 K1C19_HUMAN; P08727; B2R874; Q5XG83; Q6NW33; Q7L5M9; Q96A53; Q96FV1; Q9BYF9; Q9P1Y4 

Genbank Protein ID

 J03607; Y00503; AF202321; AK313261; AC019349; BC002539; BC007628; BC010409; BC067744; BC084574; AB045973; AB041267 

Genbank Nucleotide ID

 AAA36044.1; CAA68556.1; AAF27048.1; BAG36071.1; AAH02539.3; AAH07628.1; AAH10409.3; AAH67744.2; AAH84574.2; BAB40770.1; BAA94607.1 

Protein Name

 Keratin, type I cytoskeletal 19 

Protein Synonyms/Alias

 Cytokeratin-19; CK-19; Keratin-19; K19 

Gene Name

 KRT19 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
81	GLLAGNEKLTMQNLN	ubiquitination	[1, 2]
97	RLASYLDKVRALEAA	ubiquitination	[1]
111	ANGELEVKIRDWYQK	ubiquitination	[1, 2]
118	KIRDWYQKQGPGPSR	ubiquitination	[1, 2]
140	TIQDLRDKILGATIE	ubiquitination	[1]
168	AADDFRTKFETEQAL	ubiquitination	[1]
208	EMQIEGLKEELAYLK	sumoylation	[3]
208	EMQIEGLKEELAYLK	ubiquitination	[1]
215	KEELAYLKKNHEEEI	ubiquitination	[1]
216	EELAYLKKNHEEEIS	ubiquitination	[1]
247	APGTDLAKILSDMRS	ubiquitination	[1]
265	VMAEQNRKDAEAWFT	ubiquitination	[1]
317	LQSQLSMKAALEDTL	ubiquitination	[1]
370	YQRLMDIKSRLEQEI	ubiquitination	[1, 2]
398	YNNLSASKVL*****	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation.
 Snider NT, Weerasinghe SV, Iñiguez-Lluhí JA, Herrmann H, Omary MB.
 J Biol Chem. 2011 Jan 21;286(3):2273-84. [PMID: 21062750] 

Functional Description

 Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. 

Sequence Annotation

 REGION 1 79 Head.
 REGION 80 387 Rod.
 REGION 80 115 Coil 1A.
 REGION 116 133 Linker 1.
 REGION 134 225 Coil 1B.
 REGION 226 248 Linker 12.
 REGION 244 390 Necessary for interaction with PNN.
 REGION 249 387 Coil 2.
 REGION 388 400 Rod-like helical tail.
 MOD_RES 35 35 Phosphoserine.
 MOD_RES 391 391 Phosphotyrosine.  

Keyword

 Coiled coil; Complete proteome; Direct protein sequencing; Host-virus interaction; Intermediate filament; Keratin; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 400 AA 

Protein Sequence

Gene Ontology

 GO:0071944; C:cell periphery; IDA:MGI.
 GO:0043034; C:costamere; IDA:UniProtKB.
 GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:Compara.
 GO:0005882; C:intermediate filament; TAS:ProtInc.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
 GO:0008307; F:structural constituent of muscle; IDA:UniProtKB.
 GO:0060706; P:cell differentiation involved in embryonic placenta development; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEP:UniProtKB.
 GO:0045214; P:sarcomere organization; IDA:UniProtKB.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR002957; Keratin_I.
 IPR009053; Prefoldin. 

Pfam

 PF00038; Filament 

SMART

  

PROSITE

 PS00226; IF 

PRINTS

 PR01248; TYPE1KERATIN.