CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005772
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA-3-methyladenine glycosylase 
Protein Synonyms/Alias
 3-alkyladenine DNA glycosylase; 3-methyladenine DNA glycosidase; ADPG; N-methylpurine-DNA glycosylase 
Gene Name
 MPG 
Gene Synonyms/Alias
 AAG; ANPG; MID1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
80SIYFSSPKGHLTRLGubiquitination[1, 2]
229CQALAINKSFDQRDLubiquitination[1, 2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. 
Sequence Annotation
 MOD_RES 78 78 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; DNA damage; DNA repair; Hydrolase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 298 AA 
Protein Sequence
MVTPALQMKK PKQFCRRMGQ KKQRPARAGQ PHSSSDAAQA PAEQPHSSSD AAQAPCPRER 60
CLGPPTTPGP YRSIYFSSPK GHLTRLGLEF FDQPAVPLAR AFLGQVLVRR LPNGTELRGR 120
IVETEAYLGP EDEAAHSRGG RQTPRNRGMF MKPGTLYVYI IYGMYFCMNI SSQGDGACVL 180
LRALEPLEGL ETMRQLRSTL RKGTASRVLK DRELCSGPSK LCQALAINKS FDQRDLAQDE 240
AVWLERGPLE PSEPAVVAAA RVGVGHAGEW ARKPLRFYVR GSPWVSVVDR VAEQDTQA 298 
Gene Ontology
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003684; F:damaged DNA binding; TAS:ProtInc.
 GO:0008725; F:DNA-3-methyladenine glycosylase activity; IEA:EC.
 GO:0052822; F:DNA-3-methylguanine glycosylase activity; IEA:EC.
 GO:0052821; F:DNA-7-methyladenine glycosylase activity; IEA:EC.
 GO:0043916; F:DNA-7-methylguanine glycosylase activity; IEA:EC.
 GO:0045007; P:depurination; TAS:Reactome.
 GO:0006307; P:DNA dealkylation involved in DNA repair; TAS:ProtInc. 
Interpro
 IPR011034; Formyl_transferase_C-like.
 IPR003180; PurDNA_glycsylse. 
Pfam
 PF02245; Pur_DNA_glyco 
SMART
  
PROSITE
  
PRINTS