CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004851
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 POU domain, class 3, transcription factor 2 
Protein Synonyms/Alias
 Brain-specific homeobox/POU domain protein 2; Brain-2; Brn-2; Nervous system-specific octamer-binding transcription factor N-Oct-3; Octamer-binding protein 7; Oct-7; Octamer-binding transcription factor 7; OTF-7 
Gene Name
 POU3F2 
Gene Synonyms/Alias
 BRN2; OCT7; OTF7 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
330KLKPLLNKWLEEADSubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity). 
Sequence Annotation
 DOMAIN 262 336 POU-specific.
 DNA_BIND 354 413 Homeobox.
 MOD_RES 341 341 Phosphoserine.  
Keyword
 Activator; Alternative initiation; Complete proteome; DNA-binding; Homeobox; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 443 AA 
Protein Sequence
MATAASNHYS LLTSSASIVH AEPPGGMQQG AGGYREAQSL VQGDYGALQS NGHPLSHAHQ 60
WITALSHGGG GGGGGGGGGG GGGGGGGGDG SPWSTSPLGQ PDIKPSVVVQ QGGRGDELHG 120
PGALQQQHQQ QQQQQQQQQQ QQQQQQQQQR PPHLVHHAAN HHPGPGAWRS AAAAAHLPPS 180
MGASNGGLLY SQPSFTVNGM LGAGGQPAGL HHHGLRDAHD EPHHADHHPH PHSHPHQQPP 240
PPPPPQGPPG HPGAHHDPHS DEDTPTSDDL EQFAKQFKQR RIKLGFTQAD VGLALGTLYG 300
NVFSQTTICR FEALQLSFKN MCKLKPLLNK WLEEADSSSG SPTSIDKIAA QGRKRKKRTS 360
IEVSVKGALE SHFLKCPKPS AQEITSLADS LQLEKEVVRV WFCNRRQKEK RMTPPGGTLP 420
GAEDVYGGSR DTPPHHGVQT PVQ 443 
Gene Ontology
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0001105; F:RNA polymerase II transcription coactivator activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0014002; P:astrocyte development; IEA:Compara.
 GO:0071310; P:cellular response to organic substance; IEA:Compara.
 GO:0021799; P:cerebral cortex radially oriented cell migration; IEA:Compara.
 GO:0008544; P:epidermis development; IEA:Compara.
 GO:0021869; P:forebrain ventricular zone progenitor cell division; IEA:Compara.
 GO:0021979; P:hypothalamus cell differentiation; IEA:Compara.
 GO:0022011; P:myelination in peripheral nervous system; IEA:Compara.
 GO:0021985; P:neurohypophysis development; IEA:Compara.
 GO:0030182; P:neuron differentiation; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
 GO:0040018; P:positive regulation of multicellular organism growth; IEA:Compara.
 GO:0050770; P:regulation of axonogenesis; IEA:Compara. 
Interpro
 IPR017970; Homeobox_CS.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR010982; Lambda_DNA-bd_dom.
 IPR013847; POU.
 IPR000327; POU_specific.
 IPR016362; Transcription_factor_POU. 
Pfam
 PF00046; Homeobox
 PF00157; Pou 
SMART
 SM00389; HOX
 SM00352; POU 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2
 PS00035; POU_1
 PS00465; POU_2
 PS51179; POU_3 
PRINTS
 PR00028; POUDOMAIN.