CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016647
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcriptional-regulating factor 1 
Protein Synonyms/Alias
 Transcriptional-regulating protein 132; Zinc finger transcription factor TReP-132 
Gene Name
 Trerf1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
188LRQLLSQKPVEPSASacetylation[1]
639PVLEIPRKHPPIAAKacetylation[1, 2, 3]
646KHPPIAAKVEEPLKNacetylation[1, 2, 3]
1160LDQLSLMKPVKDVDIacetylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. 
Sequence Annotation
 DOMAIN 785 876 ELM2.
 DOMAIN 891 942 SANT.
 ZN_FING 512 534 C2H2-type 1.
 ZN_FING 1019 1043 C2H2-type 2.
 ZN_FING 1092 1114 C2H2-type 3.
 MOD_RES 773 773 Phosphothreonine (By similarity).
 MOD_RES 960 960 Phosphothreonine (By similarity).
 MOD_RES 961 961 Phosphoserine (By similarity).
 MOD_RES 980 980 Phosphoserine.  
Keyword
 Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1205 AA 
Protein Sequence
MGDQQLYKTN HVGHGGENLF YQQPPLGVHS GLGHSYGNTI SGAGMDAPQA SPISPHFPQD 60
TRDGLGLPIG SKNLGQMDTS RQGGWGSHAG PGNHVQLRSN LANSNMMWGT PTQVEPADGY 120
QYTYSQASEI RTQKLTSGVL HKLDSFTQVF ANQNLRIQVN NMAQVLHTQS AVMDGASDSA 180
LRQLLSQKPV EPSASAIASR YQQVPQQPHP GFTGGLPKPA LPVGQHAPQG HLYYDYQQPL 240
AQMSMQGGQP LQAPQVLSGH MQQLQQHQYY PQPPPQQQQA GLQRISVQEM QQQQQPQQIR 300
PSPPQQQQQL QLQQRQSSLQ IPQYYQPQPM MQHLQEQQQP SMHLQPPSYH RDPHQYTPEQ 360
AHAVQLIQLG SMPQYYYQEP QQAYSHPLYP QSHLSQHQQR EDGQLKTYSS DRQTPAMLSS 420
HGDMGTSDTG VADPASSEMT RVTSTLPHQP LLSPSGIHLN NMGSQHQQPP SPSAMWPQMH 480
LPDGRAQSGS PESSSGQTKG VFGEQFDAKN KLTCSICLKE FKSLPALNGH MRSHGGMRAS 540
PSLKQEEGEK APPPQPQPQP QPQQPLPPPP PPPPPPQLPP EAERLTPMVM PVSVPVKLIP 600
PKPSSQGFTN SVAATPAARD KPASSMSDDE MPVLEIPRKH PPIAAKVEEP LKNLPEKKKF 660
RHRPEPLFIP PPPSSYTPNP TSYSGATLYQ SQLRSPRILG DHLLLDPAHE LPPYTPPPML 720
SPVRQGSGLF SNVLISGHGP GVHPQLPLTP LTPTPRVLLC RSSSIDGSNV TVTPGPGEQT 780
VDVEPRINIG LRFQAEIPEL QDVSALAQDT HRATLVWKPW PELENQALQQ QVENLLNLCC 840
SSALPGGGTN SEFALHSLFE AKGDVMATLE MLLLRKPVRL KCHPLANYHY AGSDKWTSLE 900
RKLFNKALAT YSKDFIFVQK MVKSKTVAQC VEYYYTWKKI MRLGRKHRTR LAEIIDDCMT 960
SEEEEEAEEE EEDPEEDRKS IKEEESEVAK SPEPPPAPAL APTEGPPMQA VGQQPSGNFI 1020
CEMPNCGAVF SSRQALNGHA RIHGGTNQVA KTRGAIPSGK QKPGGTQSGY CSVKSSPSHS 1080
TTSGETDPTT IFPCKECGKV FFKIKSRNAH MKTHRQQEEQ QRQKAQKAAF AAEMAATIER 1140
TTGPVGAPEL LPLDQLSLMK PVKDVDILDD DVVQQLGVMD EAEVVGTDLL LDDQDSVLLQ 1200
GDTEL 1205 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000949; ELM2_dom.
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01448; ELM2 
SMART
 SM00717; SANT
 SM00355; ZnF_C2H2 
PROSITE
 PS51156; ELM2
 PS51293; SANT
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS