UniProt Accession

 SUN2_HUMAN; Q9UH99; B0QY62; O75156; Q2NKN8; Q504T5; Q6B4H1; Q7Z3E3 

Genbank Protein ID

 AB014568; AY682988; CR456474; BX537962; AL008583; AL021806; AL021707; AL021707; BC030684; BC094797; BC111717; AF202723 

Genbank Nucleotide ID

 BAA31643.1; AAT90500.1; CAG30360.1; CAD97926.1; CAI21604.1; CAQ07913.1; AAH30684.2; AAH94797.1; AAI11718.1; AAF15887.1 

Protein Name

 SUN domain-containing protein 2 

Protein Synonyms/Alias

 Protein unc-84 homolog B; Rab5-interacting protein; Rab5IP; Sad1/unc-84 protein-like 2 

Gene Name

 SUN2 

Gene Synonyms/Alias

 FRIGG; KIAA0668; RAB5IP; UNC84B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
300	EFSSNWQKEAMRLER	ubiquitination	[1, 2, 3]
344	SRREAALKEDFRRET	ubiquitination	[2]
375	QDSEDLFKKIVRASQ	ubiquitination	[1, 2, 3]
392	EARIQQLKSEWQSMT	ubiquitination	[1, 2, 3]
409	SFQESSVKELRRLED	ubiquitination	[1, 2, 3]
491	QLRELESKILTHVAE	ubiquitination	[2, 3]
502	HVAEMQGKSAREAAA	ubiquitination	[1, 2]
533	EQVHHIVKQALQRYS	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. 

Sequence Annotation

 DOMAIN 555 716 SUN.
 REGION 1 139 LMNA-binding (By similarity).
 MOD_RES 12 12 Phosphoserine.
 MOD_RES 38 38 Phosphoserine.
 MOD_RES 54 54 Phosphoserine.
 MOD_RES 116 116 Phosphoserine.
 CARBOHYD 636 636 N-linked (GlcNAc...).  

Keyword

 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Endosome; Glycoprotein; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 717 AA 

Protein Sequence

Gene Ontology

 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0034993; C:SUN-KASH complex; IDA:UniProtKB.
 GO:0005521; F:lamin binding; IDA:UniProtKB.
 GO:0008017; F:microtubule binding; TAS:UniProtKB.
 GO:0051642; P:centrosome localization; ISS:UniProtKB.
 GO:0090286; P:cytoskeletal anchoring at nuclear membrane; IDA:UniProtKB.
 GO:0007052; P:mitotic spindle organization; TAS:UniProtKB.
 GO:0006998; P:nuclear envelope organization; IGI:MGI.
 GO:0090292; P:nuclear matrix anchoring at nuclear membrane; IDA:UniProtKB.
 GO:0031022; P:nuclear migration along microfilament; ISS:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB. 

Interpro

 IPR012919; Sad1_UNC_C. 

Pfam

 PF07738; Sad1_UNC 

SMART

  

PROSITE

 PS51469; SUN 

PRINTS