| Tag | Content |
|---|
| CPLM ID | CPLM-007334 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein RIC1 |
Protein Synonyms/Alias | Ribosome control protein 1 |
Gene Name | RIC1 |
Gene Synonyms/Alias | YLR039C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 739 | RKFIKLGKVDGGGWQ | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | The RIC1-RGP1 complex formed with RGP1 acts as a guanine nucleotide exchange factor (GEF), which activates YPT6 by exchanging bound GDP for free GTP. It is thereby required for efficient fusion of endosome-derived vesicles with the Golgi. The RIC1-RGP1 participates in the recycling of SNC1, presumably by mediating fusion of endosomal vesicles with the Golgi compartment. May also be indirectly involved in the transcription of both ribosomal protein genes and ribosomal RNA. |
Sequence Annotation | |
Keyword | Complete proteome; Golgi apparatus; Guanine-nucleotide releasing factor; Membrane; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1056 AA |
Protein Sequence | MFIKQSEKNT PKCLYKKKGK VRVLLTGSCK KLNTWKMHLW PVSPPQLLRI PPRNAELGEG 60
TKIDDCNILQ SMTLPQANVL IMLTPTRVLI YNFKPMALVA SHERTMASLK EFGDNRSMKR 120
SAPYNDIIEG LISKKDSQYL LWHQGKLIFY VMTDKNFLLT YQILKNCTNE IIFKEYGIPV 180
IEPLLMSEEE ANSAEYDYNN DDDTLTVFDK NSSSRIIQNG FGITKEKGFL HFLSNQENID 240
ELPVKKLELR LKVVLKFDYE IIDMIGIKTF SKVGDGRYEE VLIVLFPHGL QILTISDFKV 300
SKSSLVEVKK GSKTIVCNKQ LMVLSHDSVE KQTIVSIIDI EKQAVEAIPL TDTPDELLTC 360
LEVNGYLVVV YKEKIICFDT RIKKVSHSWK PPFVIKLCDK INDKILLLVS EDSVNIHFYT 420
EFGNLLFATY FDEDDYNGDN NNDNSKDKNE KKAAEYKISD FVCLDKSLIT VSHSGKYQVW 480
KLWEEIKQTQ FDFRNPKCYV LTNTNNDVII YSPVTSSSIN NDNLQVIKLP TKTFNNHIAF 540
VKINSSLRLF ATYVSNKNIL LIHNLETNMW SSFADQNVLD LHWLGDNYLV CHMKNDDGST 600
NLKCLQIPLQ EANPDVELSD YVMWEYNVPE NTIVFSLHVN TLSRYKLLKM KSKNHNASEK 660
QPDALLKTAE IILVTDTQTI VFDVISTVHP CGLNIIKKFY QYLKINIPID VLPNKIEWII 720
NMKEGLLFFA DRKFIKLGKV DGGGWQTLTL LDNIEKIIDV IRDEIFVVQG HNYVVYSLED 780
LWDDKKPLVS IPIEEDLYPI STTPETATTH TLHCIFNARF SKLVVKHQIY LDQLILAKLE 840
DNTDLEDISH NYRFLKPYKF ALEKILSTKI LRSDSLDDIL KLIKMYDNTD PEHNISPPTH 900
SGMLEIISNC LRKIETKYWN HLFTNLKMTP RDLLALCIEE NEAKMLGVLL LVFLNYDEKD 960
LGDDLHFKKS DLGTEESKAL NDNSTKKSEK SVTNLLKDEE LMLKVLELLV TSAANATDPI 1020
KATDSWDMCF QLIRLLKELD RENNTQLVQK ALERFK 1056 |
Gene Ontology | GO:0000139; C:Golgi membrane; IDA:SGD. GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:SGD. GO:0005634; C:nucleus; ISS:SGD. GO:0034066; C:Ric1p-Rgp1p complex; IPI:SGD. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. GO:0006886; P:intracellular protein transport; IMP:SGD. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0042147; P:retrograde transport, endosome to Golgi; IMP:SGD. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |