CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028241
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CG5591 
Protein Synonyms/Alias
 HL01030p 
Gene Name
 Lpt 
Gene Synonyms/Alias
 CG5591; Dmel_CG5591 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
434ELDPLEGKPTMDPSSacetylation[1]
465SVRGRSGKFVLHRMGacetylation[1]
1343GTEPIGDKKLRNLLQacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1482 AA 
Protein Sequence
MSTNVVVSME EKAVADDLPY FPEKFPGKVC CLCNLGEKSA LGQGEILQLK APAPAEIKDK 60
YPTDRLREDG SRLLYGPKQA ASSSGDCHYE LDKIGQPDVV HPAEFLDEGF VYVHRMCIMW 120
SLRKSQISDA DGAYFATHFA EFLEQKCNFC GRYGASINCK MNCRQVHHWP CAAAAGCLLI 180
LESFTVFCTE HLSQVPVICS DNNVECLSCS SLGDLSKLIM CSTCGDHFHS TCIGLANLPD 240
TRSGWNCARC TKCQICRQQD SNDTKYVKCE QCQKTYHASC LRPVISAIPK YGWKCNRCRV 300
CTDCGSRTPG GGSSSRWHSH YTICDSCYQQ RNKGFSCPIC QKAYRAASHK EMVKCSWCNK 360
FVHSTCDEEA DLTAYHKKKE QNPDYDYVCP NCKSNSSGPG SSQQTIDSIV LSAMDSSSEQ 420
LSLKEIELDP LEGKPTMDPS SDELHKLPTG KKKVCLTSVR GRSGKFVLHR MGVMSQINKK 480
RSTRGKGRQL ALPTISSDRC LSRSMETDLT SDKKLLLCSA RDKFIQAQDI CVMCGSLGIE 540
SDSVMITCAQ CGQCYHPYCA GVKPSRGILQ KGWRCLDCTV CEGCGKKNDE ARLLLCDECD 600
ISYHIYCVNP PLETVPTGNW KCSFCTLCQK CGRNPTEKSE FGDSNMLECP SCTSQSSCPV 660
CKVSYSNGEM IIQCEHCELW AHFHCDSVNA QLTIDHYDNN VYKCFKCRCS TRSTNSLADA 720
KFGNEDSLAI TPQGSKPFVH ITASSGPSFD SKSGAERNHP TLSGDMPESA PEALHWIDGV 780
CLSESGLGMI KSLSTEIKRK RKMRQALGNG KDGQLEAAAE EALEKYKDGM VWDGTENAIP 840
EGFTISINDE GVNILRKKRQ RNLQKLGIGG FSVRNRGLKK DSEETTAVDQ INSLMTMDKK 900
KKIIRKKQKN KLIEAYPVYL QEAFFGKPLL EGGELVMADT DSSDEIDASM KVYFTRPEGK 960
SPANQDTLAV NKSPAKTVKK VKAELKTENK TVFIQQMPMG IQNKNGTTPV SNVFDPLQAE 1020
ISNTVFANRH PLDALASPNV PELDMANSVS TVPSAEVIEK PMRESPAVLV DSFMVPNQLP 1080
QEQKFHNQLY LGGNTLVNPA QQLQFRQQAP QNANKQNMQT IMSQVVLQTE KRPEEEQKVV 1140
EPVTETLNAG TQKTAEKMRK DEDLGLMATI SAVLYANTEH PNLKELFPIW NDRCKQILKR 1200
WRSLCNEKKA PFLQKAKDNR SALRQRREQN KIPMPPKPQK QEEMGRVWKQ PPKLKEDQPN 1260
MFVTYNGNAY DMGNYVGGSA QAASNNPNPH HVMPNVNDNL VIKATMQRTQ VHTTAASTLK 1320
MTTVDNRLEL NTAVYGTEPI GDKKLRNLLQ KNSTEPMLMG ANSDLFLGND VMRLGMMQNT 1380
PITQNNPMLS ISGKSQPSEG RSLEQDVKLG EPQEATSSAV ELENVGFSDL LGGLGEGDDD 1440
DLLKSLTSEM GDDFNILEYA DPELDVNVLN SLDFDDNEKC ST 1482 
Gene Ontology
 GO:0008230; C:ecdysone receptor holocomplex; IPI:FlyBase.
 GO:0044666; C:MLL3/4 complex; IDA:FlyBase.
 GO:0005700; C:polytene chromosome; IDA:FlyBase.
 GO:0003682; F:chromatin binding; IDA:FlyBase.
 GO:0042393; F:histone binding; IDA:FlyBase.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:FlyBase.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0018990; P:ecdysis, chitin-based cuticle; IMP:FlyBase.
 GO:0035076; P:ecdysone receptor-mediated signaling pathway; IGI:FlyBase.
 GO:0051568; P:histone H3-K4 methylation; IDA:FlyBase.
 GO:0007474; P:imaginal disc-derived wing vein specification; IMP:FlyBase.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
 GO:1900114; P:positive regulation of histone H3-K9 trimethylation; IMP:FlyBase. 
Interpro
 IPR009071; HMG_box_dom.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00628; PHD 
SMART
 SM00109; C1
 SM00398; HMG
 SM00249; PHD
 SM00184; RING 
PROSITE
 PS50016; ZF_PHD_2 
PRINTS