UniProt Accession

 PFD6_MOUSE; Q03958 

Genbank Protein ID

 M65255; M65256; AF100956; AK076015; BC022974 

Genbank Nucleotide ID

 AAA39368.1; AAA39369.1; AAC69895.1; BAC36121.1; AAH22974.1 

Protein Name

 Prefoldin subunit 6 

Protein Synonyms/Alias

 Protein Ke2 

Gene Name

 Pfdn6 

Gene Synonyms/Alias

 H2-Ke2; Pfd6 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
66	LLGPVLVKQELGEAR	ubiquitination	[1]
88	DYITAEIKRYESQLR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). 

Sequence Annotation

 MOD_RES 21 21 N6-acetyllysine (By similarity).
 MOD_RES 66 66 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Chaperone; Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 127 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0016272; C:prefoldin complex; IEA:Compara.
 GO:0051131; P:chaperone-mediated protein complex assembly; IEA:Compara.
 GO:0006457; P:protein folding; IEA:InterPro. 

Interpro

 IPR002777; PFD_beta-like.
 IPR009053; Prefoldin. 

Pfam

 PF01920; Prefoldin_2 

SMART

  

PROSITE

  

PRINTS