UniProt Accession

 PSB2_MOUSE; Q9R1P3 

Genbank Protein ID

 AF060090; BC008265 

Genbank Nucleotide ID

 AAD50535.1; AAH08265.1 

Protein Name

 Proteasome subunit beta type-2 

Protein Synonyms/Alias

 Macropain subunit C7-I; Multicatalytic endopeptidase complex subunit C7-I; Proteasome component C7-I 

Gene Name

 Psmb2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
29	ASNIVQMKDDHDKMF	ubiquitination	[1]
68	QKNVQLYKMRNGYEL	acetylation	[2]
68	QKNVQLYKMRNGYEL	ubiquitination	[1]
162	RAVELLRKCLEELQK	ubiquitination	[1]
185	FSVRVIDKDGIHNLE	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a chymotrypsin-like activity. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleus; Protease; Proteasome; Reference proteome; Threonine protease. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005839; C:proteasome core complex; IDA:UniProtKB.
 GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0051603; P:proteolysis involved in cellular protein catabolic process; IEA:InterPro.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0010243; P:response to organic nitrogen; IEA:Compara. 

Interpro

 IPR016050; Proteasome_bsu_CS.
 IPR001353; Proteasome_sua/b.
 IPR023333; Proteasome_suB-type. 

Pfam

 PF00227; Proteasome 

SMART

  

PROSITE

 PS00854; PROTEASOME_B_1
 PS51476; PROTEASOME_B_2 

PRINTS