CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031121
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myotubularin-related protein 9 
Protein Synonyms/Alias
 cDNA FLJ60798, highly similar to Homo sapiens myotubularin related protein 8 (MTMR8), mRNA 
Gene Name
 MTMR8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
128EMRESGWKLIDPISDubiquitination[1]
255MANRAAGKGYENEDNubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 693 AA 
Protein Sequence
MDHITVPKVE NVKLVDRYVS KKPANGILYL TATHLIYVEA SGAARKETWI ALHHIATVEK 60
LPITSLGCPL TLRCKNFRVA HFVLDSDLVC HEVYISLLKL SQPALPEDLY AFSYNPKSSK 120
EMRESGWKLI DPISDFGRMG IPNRNWTITD ANRNYEICST YPPEIVVPKS VTLGTVVGSS 180
KFRSKERVPV LSYLYKENNA AICRCSQPLS GFYTRCVDDE LLLEAISQTN PGSQFMYVVD 240
TRPKLNAMAN RAAGKGYENE DNYANIRFRF MGIENIHVMR SSLQKLLEVC ELKTPTMSEF 300
LSGLESSGWL RHIKAIMDAG IFITKAVKVE KASVLVHCSD GWDRTAQVCS VASILLDPFY 360
RTFKGLMIWH FLVLIMRIVL QLAKMNLMDI TKIFSLLQPD KEEEDTDTEE KQALNQAVYD 420
NDSYTLDQLL RQERYKRFIN SRSGWGVPGT PLRLAASYGH LSCLQVLLAH GADVDSLDVK 480
AQTPLFTAVS HGHLDCVRVL LEAGASPGGS IYNNCSPVLT AARDGAVAIL QELLDHGAEA 540
NVKAKLPVWA SNIASCSGPL YLAAVYGHLD CFRLLLLHGA DPDYNCTDQG LLARVPRPRT 600
LLEICLHHNC EPEYIQLLID FGANIYLPSL SLDLTSQDDK GIALLLQARA TPRSLLSQVR 660
LVVRRALCQA GQPQAINQLD IPPMLISYLK HQL 693 
Gene Ontology
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR010569; Myotub-related.
 IPR017906; Myotubularin_phosphatase_dom.
 IPR001496; SOCS_C.
 IPR016130; Tyr_Pase_AS. 
Pfam
 PF00023; Ank
 PF12796; Ank_2
 PF06602; Myotub-related
 PF07525; SOCS_box 
SMART
 SM00248; ANK
 SM00969; SOCS_box 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS51339; PPASE_MYOTUBULARIN
 PS00383; TYR_PHOSPHATASE_1 
PRINTS