CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018378
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein ELYS 
Protein Synonyms/Alias
 Embryonic large molecule derived from yolk sac; Protein MEL-28; Putative AT-hook-containing transcription factor 1 
Gene Name
 AHCTF1 
Gene Synonyms/Alias
 ELYS; TMBS62; MSTP108 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
978ANYVPALKLNQTLKIubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. 
Sequence Annotation
 DNA_BIND 1971 1983 A.T hook.
 REGION 1 981 Necessary for cytoplasmic localization
 REGION 1149 2266 Necessary for nuclear localization (By
 REGION 1446 1698 Mediates transcriptional activity (By
 MOD_RES 528 528 Phosphoserine.
 MOD_RES 1142 1142 Phosphoserine.
 MOD_RES 1150 1150 Phosphoserine.
 MOD_RES 1155 1155 Phosphoserine.
 MOD_RES 1160 1160 Phosphoserine.
 MOD_RES 1175 1175 Phosphothreonine.
 MOD_RES 1214 1214 Phosphoserine.
 MOD_RES 1222 1222 Phosphoserine.
 MOD_RES 1232 1232 Phosphoserine.
 MOD_RES 1250 1250 Phosphoserine.
 MOD_RES 1283 1283 Phosphoserine.
 MOD_RES 1297 1297 Phosphoserine.
 MOD_RES 1369 1369 Phosphothreonine.
 MOD_RES 1371 1371 Phosphoserine (By similarity).
 MOD_RES 1513 1513 Phosphoserine.
 MOD_RES 1517 1517 Phosphothreonine.
 MOD_RES 1533 1533 Phosphoserine.
 MOD_RES 1541 1541 Phosphoserine.
 MOD_RES 1729 1729 Phosphoserine.
 MOD_RES 1806 1806 Phosphoserine.
 MOD_RES 1808 1808 Phosphothreonine.
 MOD_RES 1878 1878 Phosphoserine.
 MOD_RES 1884 1884 Phosphoserine.
 MOD_RES 1898 1898 Phosphoserine.
 MOD_RES 1944 1944 Phosphoserine.
 MOD_RES 1946 1946 Phosphoserine.
 MOD_RES 1996 1996 Phosphoserine.
 MOD_RES 2043 2043 Phosphoserine.
 MOD_RES 2044 2044 Phosphoserine.
 MOD_RES 2060 2060 Phosphoserine.
 MOD_RES 2089 2089 Phosphoserine.
 MOD_RES 2120 2120 Phosphoserine.
 MOD_RES 2123 2123 Phosphoserine.
 MOD_RES 2154 2154 Phosphoserine.
 MOD_RES 2212 2212 Phosphoserine.
 MOD_RES 2222 2222 Phosphoserine.
 MOD_RES 2226 2226 Phosphoserine.  
Keyword
 Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; DNA-binding; Kinetochore; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2266 AA 
Protein Sequence
MAAERRCGSM RDLRAQVTSG LLPFPEVTLQ ALGEDEITLE SVLRGKFAAG KNGLACLACG 60
PQLEVVNSIT GERLSAYRFS GVNEQPPVVL AVKEFSWQKR TGLLIGLEET EGSVLCLYDL 120
GISKVVKAVV LPGRVTAIEP IINHGGASAS TQHLHPSLRW LFGVAAVVTD VGQILLVDLC 180
LDDLSCNQNE VEASDLEVLT GIPAEVPHIR ESVMRQGRHL CFQLVSPTGT AVSTLSYISR 240
TNQLAVGFSD GYLALWNMKS MKREYYIQLE SGQVPVYAVT FQEPENDPRN CCYLWAVQST 300
QDSEGDVLSL HLLQLAFGNR KCLASGQILY EGLEYCEERY TLDLTGGMFP LRGQTSNTKL 360
LGCQSIEKFR SHGDREEGVN EALSPDTSVS VFTWQVNIYG QGKPSVYLGL FDINRWYHAQ 420
MPDSLRSGEY LHNCSYFALW SLESVVSRTS PHGILDILVH ERSLNRGVPP SYPPPEQFFN 480
PSTYNFDATC LLNSGVVHLT CTGFQKETLT FLKKSGPSLN ELIPDGYNRC LVAGLLSPRF 540
VDVQPSSLSQ EEQLEAILSA AIQTSSLGLL TGYIRRWITE EQPNSATNLR FVLEWTWNKV 600
VLTKEEFDRL CVPLFDGSCH FMDPQTIQSI QQCYLLLSNL NIVLSCFASE AREITERGLI 660
DLSNKFVVSH LICQYAQVVL WFSHSGLLPE GIDDSVQLSR LCYNYPVIQN YYTSRRQKFE 720
RLSRGKWNPD CLMIDGLVSQ LGERIEKLWK RDEGGTGKYP PASLHAVLDM YLLDGVTEAA 780
KHSITIYLLL DIMYSFPNKT DTPIESFPTV FAISWGQVKL IQGFWLIDHN DYESGLDLLF 840
HPATAKPLSW QHSKIIQAFM SQGEHRQALR YIQTMKPTVS SGNDVILHLT VLLFNRCMVE 900
AWNFLRQHCN RLNIEELLKH MYEVCQEMGL MEDLLKLPFT DTEQECLVKF LQSSASVQNH 960
EFLLVHHLQR ANYVPALKLN QTLKINVMND RDPRLRERSL ARNSILDQYG KILPRVHRKL 1020
AIERAKPYHL STSSVFRLVS RPKPLSAVPK QVVTGTVLTR SVFINNVLSK IGEVWASKEP 1080
INSTTPFNSS KIEEPSPIVY SLPAPELPEA FFGTPISKAS QKISRLLDLV VQPVPRPSQC 1140
SEFIQQSSMK SPLYLVSRSL PSSSQLKGSP QAISRASELH LLETPLVVKK AKSLAMSVTT 1200
SGFSEFTPQS ILRSTLRSTP LASPSPSPGR SPQRLKETRI SFVEEDVHPK WIPGAADDSK 1260
LEVFTTPKKC AVPVETEWLK SKDRTTSFFL NSPEKEHQEM DEGSQSLEKL DVSKGNSSVS 1320
ITSDETTLEY QDAPSPEDLE ETVFTASKPK SSSTALTTNV TEQTEKDGDK DVFASEVTPS 1380
DLQKQMGNLE DAETKDLLVA AEAFSELNHL SPVQGTEASL CAPSVYEGKI FTQKSKVPVL 1440
DEGLTSVETY TPAIRANDNK SMADVLGDGG NSSLTISEGP IVSERRLNQE VALNLKEDHE 1500
VEVGVLKESV DLPEEKLPIS DSPPDTQEIH VIEQEKLEAQ DSGEEARNLS FNELYPSGTL 1560
KLQYNFDTID QQFCDLADNK DTAECDIAEV DGELFVAQSN FTLILEGEEG EVEPGDFASS 1620
DVLPKAANTA TEEKLVCSGE NDNHGQIANL PSAVTSDQKS QKVDTLPYVP EPIKVAIAEN 1680
LLDVIKDTRS KEITSDTMEQ SIHETIPLVS QNIMCPTKLV KSAFKTAQET STMTMNVSQV 1740
DDVVSSKTRT RGQRIQNVNV KSAQQEASAD VATPKMPGQS VRKKTRKAKE ISEASENIYS 1800
DVRGLSQNQQ IPQNSVTPRR GRRKKEVNQD ILENTSSVEQ ELQITTGRES KRLKSSQLLE 1860
PAVEETTKKE VKVSSVTKRT PRRIKRSVEN QESVEIINDL KVSTVTSPSR MIRKLRSTNL 1920
DASENTGNKQ DDKSSDKQLR IKHVRRVRGR EVSPSDVRED SNLESSQLTV QAEFDMSAIP 1980
RKRGRPRKIN PSEDVGSKAV KEERSPKKKE APSIRRRSTR NTPAKSENVD VGKPALGKSI 2040
LVPNEELSMV MSSKKKLTKK TESQSQKRSL HSVSEERTDE MTHKETNEQE ERLLATASFT 2100
KSSRSSRTRS SKAILLPDLS EPNNEPLFSP ASEVPRKAKA KKIEVPAQLK ELVSDLSSQF 2160
VISPPALRSR QKNTSNKNKL EDELKDDAQS VETLGKPKAK RIRTSKTKQA SKNTEKESAW 2220
SPPPIEIRLI SPLASPADGV KSKPRKTTEV TGTGLGRNRK KLSSYPKQIL RRKML 2275 
Gene Ontology
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0000910; P:cytokinesis; IMP:UniProtKB.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0051292; P:nuclear pore complex assembly; IMP:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR025151; ELYS_dom. 
Pfam
 PF13934; ELYS 
SMART
 SM00384; AT_hook 
PROSITE
  
PRINTS